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Chemical Structure| 135328-50-6 Chemical Structure| 135328-50-6

Structure of 135328-50-6

Chemical Structure| 135328-50-6

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Product Details of [ 135328-50-6 ]

CAS No. :135328-50-6
Formula : C10H8N2O
M.W : 172.18
SMILES Code : N#CCOC1=CC=CC2=C1NC=C2

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Application In Synthesis of [ 135328-50-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 135328-50-6 ]

[ 135328-50-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 14135-38-7 ]
  • [ 135328-50-6 ]
  • [3-(2-fluoro-phenylsulfanyl)-1H-indol-7-yloxy]-acetonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium hydride; In DMF (N,N-dimethyl-formamide); at 20℃; for 2.2h; To a solution of (LH-INDOL-7-YLOXY)-ACETONITRILE (0.244 g. , 1.42 mmol) in 15 mL anhydrous dimethylformamide was added sodium hydride (0.062 g. of a 60percent suspension in mineral oil, 1.56 mmol) portion wise). The solution was stirred with a magnetic stirrer at room temperature for 20 minutes. Bis- (2-fluorophenyl) disulfide (0.396 g. , 1.56 mmol) was added in one portion and the reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was partitioned between water (50 mL) and ethyl acetate (50 mL). The aqueous layer was extracted with ethyl acetate (2 x 25 mL) and the combined organic fractions were washed with water (2 x 25 mL) and brine (2 x 25 mL). After drying over MGS04, the organic fraction was concentrated in vacuo and the resulting dark red residue was purified by flash chromatography (chromatography (95: 5 ethyl acetate: hexanes to 85: 15 ethyl acetate: hexanes over 30 minutes) to give 0. 196 g. of [3-(2-fluoro-phenylsulfanyl)-lH-indol-7-yloxy]-acetonitrile as a clear oil. ms: (M-H)--= 297. 1
 

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