Home Cart Sign in  
Chemical Structure| 1352717-90-8 Chemical Structure| 1352717-90-8

Structure of 1352717-90-8

Chemical Structure| 1352717-90-8

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1352717-90-8 ]

CAS No. :1352717-90-8
Formula : C9H5BrFNO2
M.W : 258.04
SMILES Code : O=C1C2=CC(F)=CC(Br)=C2N=C(C)O1
MDL No. :MFCD28099289

Safety of [ 1352717-90-8 ]

Application In Synthesis of [ 1352717-90-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1352717-90-8 ]

[ 1352717-90-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1352717-90-8 ]
  • [ 1352717-91-9 ]
YieldReaction ConditionsOperation in experiment
73.7% With ammonia; In water; at 100.0℃; for 1.5h; A suspension of 8-bromo-6-fluoro-2-methyl-4H-benzo[d][1,3]oxazin-4-one (12, 466 mg, 1.81 mmol) in concd aqueous NH3 (28% v/v, 8 ml) was stirred at reflux (100 C) for 1.5 h. The reaction mixture was concentrated. The resulting precipitate was collected by filtration, washed with water (20 ml) and dried to a constant weight to afford 8-bromo-6-fluoro-2-methylquinazolin-4(3H)-one (14, 342 mg, 73.7%) as a pale white solid, which was used without further purification: (tR=2.40 min, purity=100%), ESI+m/z, no ion detected; 1H NMR (DMSO-d6), delta (ppm) 2.39 (s, 3H), 7.80 (dd, J=3.0 Hz, JH-F=8.2 Hz, 1H), 8.13 (dd, J=2.7 Hz, JH-F=8.2 Hz, 1H), 12.54 (br s, 1H); 13C NMR (DMSO-d6) delta (ppm) 21.6, 110.7 (d, JC-F=23.0 Hz), 122.9 (d, JC-F=9.7 Hz), 123.0 (d, JC-F=8.8 Hz), 126.5 (d, JC-F=26.6 Hz), 143.9 (d, JC-F=2.7 Hz), 155.3 (d, JC-F=1.8 Hz), 159.0 (d, JC-F=247.7 Hz), 161.1 (d, JC-F=3.5 Hz); HRMS m/z (ESI+) calculated for C9H7N2BrF: 256.97203; found: 256.97205.
 

Historical Records

Technical Information

Categories