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Chemical Structure| 1352398-34-5 Chemical Structure| 1352398-34-5

Structure of 1352398-34-5

Chemical Structure| 1352398-34-5

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Product Details of [ 1352398-34-5 ]

CAS No. :1352398-34-5
Formula : C10H6BrN3O
M.W : 264.08
SMILES Code : N#CC1=CN(C(C)=O)C2=NC(Br)=CC=C21
MDL No. :MFCD20923489

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Application In Synthesis of [ 1352398-34-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1352398-34-5 ]

[ 1352398-34-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1352398-34-5 ]
  • [ 612845-44-0 ]
  • [ 1413066-14-4 ]
YieldReaction ConditionsOperation in experiment
67% With triethylamine;(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; XPhos; In 1,4-dioxane; at 100℃;Inert atmosphere; Step 1. In a 100 mL round-bottomed flask, 1-acetyl-6-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile (250 mg, 947 mumol, Eq: 1.00), triethylamine (575 mg, 792 mul, 5.68 mmol, Eq: 6) and X-PHOS (181 mg, 379 mumol, Eq: 0.40) were combined with dioxane (25 ml) to give a colorless solution. [1,1'-bis(diphenylphosphino)ferrocene]dichloropaladium(II) (173 mg, 237 mumol, Eq: 0.25) and <strong>[612845-44-0]2-ethoxy-5-pyridineboronic acid</strong> (205 mg, 1.23 mmol, Eq: 1.3) were added and the resultant mixture was degassed for 5 minutes under Nitrogen. The reaction mixture was heated to 100 C. and stirred for O/N h. The reaction mixture was poured into 50 mL H2O and extracted with EtOAc (3×50 mL). The organic layers were dried over MgSO4 and concentrated in vacuo. The crude material was purified by flash chromatography (silica gel, 40 g, 20% to 30% EtOAc in hexanes) to give 6-(6-ethoxypyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile (167 mg, 67%).
 

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