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Chemical Structure| 1349151-98-9 Chemical Structure| 1349151-98-9

Structure of 1349151-98-9

Chemical Structure| 1349151-98-9

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Product Details of [ 1349151-98-9 ]

CAS No. :1349151-98-9
Formula : C14H22BNO3
M.W : 263.14
SMILES Code : O=C1C=CC(B2OC(C)(C)C(C)(C)O2)=CN1C(C)C
MDL No. :MFCD16995643
InChI Key :MPMZBWLBVFEODR-UHFFFAOYSA-N
Pubchem ID :58070386

Safety of [ 1349151-98-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1349151-98-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1349151-98-9 ]

[ 1349151-98-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1349151-98-9 ]
  • [ 116369-24-5 ]
  • 5-(4-amino-2-chloro-5-fluorophenyl)-1-isopropylpyridine-2(1H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
64% With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); potassium carbonate; In 1,4-dioxane; water; at 80℃; for 10h;Inert atmosphere; Add <strong>[116369-24-5]4-bromo-5-chloro-2-fluoroaniline</strong> (0.5 g, 2.24 mmol) to 1,4-dioxane (8.0 mL) and water (4.0 mL), and then add 1-isopropyl-5 in this order. -(4,4,5,5-tetramethyl-1,3,2-dioxorane-2-yl) pyridine-2 (1H) -one (0.65 g, 2.46 mmol),Potassium carbonate (0.94g, 6.72mmol) and Pd (dppf) Cl2 (0.1g, 0.12mmol),After replacing with nitrogen three times, the reaction was carried out at 80 C for 10 hours.After the reaction is completed, cool to room temperature, pour the reaction solution into water, extract with ethyl acetate, combine the organic phases, dry, filter, and concentrate. The residue is purified by silica gel column chromatography (eluent: ethyl acetate / petroleum ether). = 3/1),The title compound (0.4 g, yield: 64%) was obtained in this step.
 

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