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Chemical Structure| 13426-94-3 Chemical Structure| 13426-94-3

Structure of 13426-94-3

Chemical Structure| 13426-94-3

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Product Details of [ 13426-94-3 ]

CAS No. :13426-94-3
Formula : C8H12ClN
M.W : 157.64
SMILES Code : CNCC1=CC=CC=C1.[H]Cl
MDL No. :MFCD01732455

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Application In Synthesis of [ 13426-94-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 13426-94-3 ]

[ 13426-94-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 50-00-0 ]
  • [ 13426-94-3 ]
  • [ 98-86-2 ]
  • [ 21970-65-0 ]
YieldReaction ConditionsOperation in experiment
With ammonium cerium (IV) nitrate; at 90℃; for 0.166667h;Microwave irradiation; General procedure: A mixture of ketone (2.0 eq.), amine hydrochloride (1 eq.), paraformaldehyde (1 eq.), and CAN(0.05 eq.) in PEG 400 (0.8 mL) was irradiated with a microwave power of 60 watts at 90 C for 10 min.The reaction workup was performed as follows: the mixture was quenched in 2 M NaOH, thenthe solid was collected by centrifugation, dissolved in methanol or dichloromethane (depending onthe solubility of the compound), and purified using SCX cartridge, eluting with a solution of 0.3 MNH3/MeOH in dichloromethane to remove the excess ketone. Finally, the product was isolated usingsilica gel SPE cartridge, eluting with dichloromethane to remove the nonreacted amine. Then theorganic phase was evaporated to dryness.
 

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