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Chemical Structure| 1341204-97-4 Chemical Structure| 1341204-97-4

Structure of 1341204-97-4

Chemical Structure| 1341204-97-4

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Product Details of [ 1341204-97-4 ]

CAS No. :1341204-97-4
Formula : C24H34BN3O4
M.W : 439.36
SMILES Code : O=C(N1C(C2=NC=C(C3=CC=C(B4OC(C)(C)C(C)(C)O4)C=C3)N2)CCC1)OC(C)(C)C

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Application In Synthesis of [ 1341204-97-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1341204-97-4 ]

[ 1341204-97-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 960298-00-4 ]
  • [ 1341204-97-4 ]
  • 2-(5-(4-(2-benzyloxypyridin-4-yl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,2-dimethoxyethane; water; at 80 - 90℃; for 8h; A mixture of 2-Benzyloxy-4-bromo-pyridine (0.292 g), 2-{5-[4-(4,4,5,5- Tetramethyl-(1,3,2)-ldioxaborolan-2-yl)-phenyl)-1H-imidazol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester (0.533 g, prepared according to WO2008021927 A2) and Pd(PPh3)4 (0.064 g) in aq. K2CO3 solution/dimethoxyethane (1.82 mL/5.0 mL) was heated at 80-90C for 8 hours. Reaction mixture was cooled, diluted with ethyl acetate, washed with brine, dried (MgSO4) and concentrated. The residue was purified by flash column chromatography (silica gel, 20 to 80% ethyl acetate/hexanes) to give 2-{5-[4-(2-Benzyloxy-pyridin-4-yl)-phenyl]-1H-imidazol-2-yl}- pyrrolidine-1-carboxylic acid tert-butyl ester (0.530 g): LCMS-ESI+: calc'd for C30H33N4O3: 497.6 (M+H+); Found: 497.0 (M+H+).
 

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