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Chemical Structure| 1339891-76-7 Chemical Structure| 1339891-76-7

Structure of 1339891-76-7

Chemical Structure| 1339891-76-7

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Product Details of [ 1339891-76-7 ]

CAS No. :1339891-76-7
Formula : C8H6ClN3O2
M.W : 211.61
SMILES Code : O=C(C1=CC2=NC=CN2C(Cl)=N1)OC
MDL No. :MFCD28501939

Safety of [ 1339891-76-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1339891-76-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1339891-76-7 ]

[ 1339891-76-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 894807-98-8 ]
  • [ 1339891-76-7 ]
  • [ 1339891-77-8 ]
YieldReaction ConditionsOperation in experiment
With potassium phosphate;tris-(dibenzylideneacetone)dipalladium(0); XPhos; In water; isopropyl alcohol; at 80℃; for 15h;Inert atmosphere; Step C: Preparation of methyl 5-(l-((2-(trimethylsilyl)ethoxy)methvn-lH- pyrazol-4-yl)imidazo [ 1 ,2-c1pyrimidine-7-carboxylate : Methyl 5-chloroimidazo[l ,2- c]pyrimidine-7-carboxylate (1.00 g, 4.73 mmol), 4-(4,4,5,5-tetramethyl-l ,3,2-dioxaborolan- 2-yl)-l-((2-(trimethylsilyl)ethoxy)methyl)-lH-pyrazole (Preparation E; 1.53 g, 4.73 mmol), K3PO4 (2.01 g, 9.45 mmol), Pd2dba3 (0.433 g, 0.473 mmol), and XPHOS (0.563 g, 1.18 mmol) were combined dry. To this was added isopropanol (20 mL) and water (0.34 mL, 19 mmol). After de-gassing for 10 minutes, the flask was sealed and heated to 80 °C for 15 hours. The reaction mixture was diluted in EtOAc and undissolved solid was removed by filtration. The filtrate was concentrated down and purified by silica chromatography using 50-100percent EtOAc/Hexanes gradient to afford methyl 5-(l-((2-(trimethylsilyl)ethoxy)methyl)- lH-pyrazol-4-yl)imidazo[l,2-c]pyrimidine-7-carboxylate (0.477 g, 1.28 mmol, 27.0percent yield) as an orange brown solid. MS (apci) m/z = 374.1 (M+H).
 

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