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Chemical Structure| 1339452-16-2 Chemical Structure| 1339452-16-2

Structure of 1339452-16-2

Chemical Structure| 1339452-16-2

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Product Details of [ 1339452-16-2 ]

CAS No. :1339452-16-2
Formula : C7H11N3O2
M.W : 169.18
SMILES Code : O=C(C1=CC=NN1C)N(OC)C
MDL No. :MFCD18841493

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Application In Synthesis of [ 1339452-16-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1339452-16-2 ]

[ 1339452-16-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1339452-16-2 ]
  • [ 75-16-1 ]
  • [ 137890-05-2 ]
YieldReaction ConditionsOperation in experiment
In diethyl ether; at -40 - 20℃; for 16.25h;Inert atmosphere; To a stirred solution of compound 27 (6 g, 35.50 mmol) in anhydrous diethyl ether (75 mL) under inert atmosphere was added methyl magnesium bromide (23.6 mL, 71.00 mmol, 3 M sol. in diethyl ether) dropwise for 15 min at -40 oC, followed by warming to room temperature and stirring for 16 h. The reaction was monitored by TLC. After completion of the reaction, the reaction mixture was quenched with saturated ammonium chloride solution (50 mL) and extracted with diethyl ether. The combined organic extracts were dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to afford compound 28 (5g, crude) as pale brown liquid. TLC: 20% EtOAc/ hexanes (Rf: 0.4); 1H NMR (400 MHz, CDCl3): delta 7.46 (d, J = 2.0 Hz, 1H), 6.83 (d, J = 2.1 Hz, 1H), 4.16 (s, 3H), 2.52 (s, 3H); LCMS Calculated for C6H8N2O: 124.06; Observed: 124.9 (M+1)+.
 

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