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Chemical Structure| 1338926-80-9 Chemical Structure| 1338926-80-9

Structure of 1338926-80-9

Chemical Structure| 1338926-80-9

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Product Details of [ 1338926-80-9 ]

CAS No. :1338926-80-9
Formula : C16H21NO3
M.W : 275.34
SMILES Code : O=C(OC(C)(C)C)NC1CCC2=C1C=CC(C(C)=O)=C2

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Application In Synthesis of [ 1338926-80-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1338926-80-9 ]

[ 1338926-80-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1190865-44-1 ]
  • [ 1338926-80-9 ]
  • tert-butyl N-[5-[3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluoro-but-2-enoyl]indan-1-yl]carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
38% With calcium hydroxide; In N,N-dimethyl-formamide; toluene; at 120℃; A solution of the product of step 7 (20 g) and 1 -(3,5-dichloro-4-fluoro-phenyl)-2,2,2-trifluoro-ethanone (30 g, CAS 1190865-44-1) in a mixture of toluene (1 L) and DMF(200 mL) was treated with Ca(OH)2 (9 g) and heated at 120C overnight. The reactionwas diluted with water and extracted with EtOAc. The organic layer was dried(Na2504), filtered, and concentrated. The residue was purified by flash chromatography on silica to afford the title product (15 g, 38%).1H NMR (400 MHz, 0D013): 7.7 (m, 2H), 7.4 (m, 2H), 7.3-7.2 (m, 2H), 5.2 (m, 1 H), 4.7 (m, 1H), 3.0-2.9 (m, 1H), 2.9-2.8 (m, 1H), 2.7-2.6 (m, 1H), 1.8-1.7(m, 1H), 1.5 (s, 9H).
 

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