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Chemical Structure| 1335210-23-5 Chemical Structure| 1335210-23-5
Chemical Structure| 1335210-23-5

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Dolutegravir intermediate-1 is a synthetic intermediate of Dolutegravir. Dolutegravir is an integrase inhibitor with potential for treating HIV-1 infections.

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Product Details of Dolutegravir intermediate-1

CAS No. :1335210-23-5
Formula : C13H17NO8
M.W : 315.28
SMILES Code : O=C(C1=CN(CC(OC)OC)C(C(OC)=O)=C(OC)C1=O)O
MDL No. :MFCD28978322
InChI Key :XAXGEECGULRZGN-UHFFFAOYSA-N
Pubchem ID :53469000

Safety of Dolutegravir intermediate-1

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Dolutegravir intermediate-1

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1335210-23-5 ]
  • Downstream synthetic route of [ 1335210-23-5 ]

[ 1335210-23-5 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 2749-11-3 ]
  • [ 1335210-23-5 ]
  • [ 1335210-24-6 ]
References: [1] Patent: WO2011/119566, 2011, A1, . Location in patent: Page/Page column 9.
  • 2
  • [ 1335210-23-5 ]
  • [ 1335210-24-6 ]
References: [1] Organic Letters, 2015, vol. 17, # 3, p. 564 - 567.
[2] Organic Letters, 2015, vol. 17, # 3, p. 564 - 567.
[3] Organic Letters, 2015, vol. 17, # 3, p. 564 - 567.
 

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Technical Information

• Acyl Group Substitution • Arndt-Eistert Homologation • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Bouveault-Blanc Reduction • Bucherer-Bergs Reaction • Catalytic Hydrogenation • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Ester Cleavage • Fischer Indole Synthesis • Grignard Reaction • Henry Nitroaldol Reaction • Horner-Wadsworth-Emmons Reaction • Hunsdiecker-Borodin Reaction • Hydride Reductions • Lawesson's Reagent • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Nomenclature of Ethers • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Preparation of Carboxylic Acids • Preparation of Ethers • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Amines • Reactions of Carboxylic Acids • Reactions of Ethers • Reactions with Organometallic Reagents • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Stobbe Condensation • Tebbe Olefination • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

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