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Chemical Structure| 1322001-30-8 Chemical Structure| 1322001-30-8

Structure of 1322001-30-8

Chemical Structure| 1322001-30-8

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Product Details of [ 1322001-30-8 ]

CAS No. :1322001-30-8
Formula : C6H6BNO3
M.W : 150.93
SMILES Code : O=CC1=CC=C(B(O)O)C=N1
MDL No. :MFCD06409954

Safety of [ 1322001-30-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1322001-30-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1322001-30-8 ]

[ 1322001-30-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1322001-30-8 ]
  • [ 1403257-80-6 ]
  • [ 1403258-05-8 ]
YieldReaction ConditionsOperation in experiment
57% With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; water; at 80℃; for 2h;Inert atmosphere; Step 1: Synthesis of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-5-(6-formylpyridin-3-yl)-2-methylbenzamide To a stirred solution of <strong>[1403257-80-6]5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide</strong> (1 g, 2.15 mmol) and (6-formylpyridin-3-yl)boronic acid (0.539 g, 2.31 mmol) in dioxane/water mixture (15 mL+3 mL), Na2CO3 (0.82 g, 7.74 mmol) was added and solution purged with argon for 15 min. Then Pd (PPh3)4 (0.288 g, 0.25 mmol) was added and argon was purged again for 10 min. Reaction mass was heated at 80 C. for 2 h. On completion, reaction mixture was diluted with water and extracted with 10% MeOH/DCM. Combined organic layers were dried over Na2SO4 and solvent removed under reduced pressure to afford crude material which was purified by column chromatography over silica gel to afford the desired compound (0.60 g, 57%).
 

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