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Chemical Structure| 1315362-16-3 Chemical Structure| 1315362-16-3

Structure of 1315362-16-3

Chemical Structure| 1315362-16-3

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Product Details of [ 1315362-16-3 ]

CAS No. :1315362-16-3
Formula : C9H6ClNO3
M.W : 211.60
SMILES Code : O=C(C(O1)=CC2=C1C=NC(Cl)=C2)OC
MDL No. :MFCD22552509

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Application In Synthesis of [ 1315362-16-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1315362-16-3 ]

[ 1315362-16-3 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 1060804-53-6 ]
  • [ 96-32-2 ]
  • [ 1315362-16-3 ]
YieldReaction ConditionsOperation in experiment
79% With potassium carbonate; In N,N-dimethyl-formamide; at 80℃; for 8h; j00489j To a mixture of <strong>[1060804-53-6]2-chloro-5-hydroxyisonicotinaldehyde</strong> (4.0 g, 25 mmol) and methyl 2- bromoacetate (5.8 g, 38 mmol) in N,N-dimethylformamide (40 mL) under nitrogen at room temperature was added potassium carbonate (6.9 g, 50 mmol). The reaction mixture was stirred at 80 C for 8 hours, then diluted with water (100 mL) and extracted with ethyl acetate (3 x 100 mL). The combined organic layers were washed with brine (2 x 100 mL), dried over anhydrous sodium sulfate and concentrated in vacuo. The residue was purified by silica gel silica gel chromatography [petroleum ether: ethyl acetate = 25:11 to give compound B-109 (4.2 g, 79% yield) as a white solid. LCMS (E): tR=0.68 mm., 212.6 mlz (M+1).
 

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