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Chemical Structure| 130138-46-4 Chemical Structure| 130138-46-4

Structure of 130138-46-4

Chemical Structure| 130138-46-4

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Product Details of [ 130138-46-4 ]

CAS No. :130138-46-4
Formula : C9H10N2
M.W : 146.19
SMILES Code : N#CCC1=CC(C)=NC(C)=C1

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Application In Synthesis of [ 130138-46-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 130138-46-4 ]

[ 130138-46-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 105250-16-6 ]
  • [ 151-50-8 ]
  • [ 130138-46-4 ]
YieldReaction ConditionsOperation in experiment
62% With 18-crown-6 ether; tributylphosphine; In acetonitrile; at 20℃; for 25h; Example S4: Preparation of 4- (2-Methyl-pyridin-4-yl)-2H-pyrazol-3-ylamine; a) To a stirred mixture of 4-hydroxymethyl-2-methyl-pyridine [CAS No. 105250-16-6] (3.37 g, 27.4 mmol), potassium cyanide (3.56 g, 54.7 mmol) and 18-crown-6 (0.72 g, 2.74 mmol) in acetonitrile (75 ml) was added dropwise at 15-20C a solution of tributylphosphine (7.16 g, 30.1 mmol) in acetonitrile (25 ml). The reaction mixture was stirred at room temperature for 25 h, poured into water (100 ml) and extracted with ethyl acetate (3 x 100 ml). The combined organic layers were washed with water (3 x 100 ml), brine (100 ml) dried (MgSO4) and evaporated. The crude product was further purified by column chromatography on silica gel (ethyl acetate) to yield 4-cyanomethyl- 2-methyl-pyridine (2.26 g, 62%) as a brown oil
 

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