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Chemical Structure| 129999-45-7 Chemical Structure| 129999-45-7

Structure of 129999-45-7

Chemical Structure| 129999-45-7

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Product Details of [ 129999-45-7 ]

CAS No. :129999-45-7
Formula : C9H18N2O2
M.W : 186.25
SMILES Code : OC1CCN(C(CN(C)C)=O)CC1

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Application In Synthesis of [ 129999-45-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 129999-45-7 ]

[ 129999-45-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 574745-97-4 ]
  • [ 129999-45-7 ]
  • [ 848438-63-1 ]
YieldReaction ConditionsOperation in experiment
94% With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In dichloromethane; at 0 - 20℃; for 1h; DI-TE7ZT-BUTYLAZADICARBOXYLATE (759 mg, 3.3 mmol) was added portionwise to an ice- cooled solution of <strong>[574745-97-4]4-chloro-7-methoxyquinazolin-6-ol</strong> (462 mg, 2.2 mmol), 1- dimethylaminoacetyl-4-hydroxypiperidine (490 mg, 2.6 mmol, prepared as described in example 9, preparation of starting materials) and triphenylphosphine (865 mg, 3.3 mmol) in dichloromethane (20 ml). The mixture was stirred at room temperature for 1 hour. After evaporation of the solvent under vacuum, the residue was purified by chromatography on silica gel (eluant: 0% to 2% 7N methanolic ammonia in dichloromethane) to give 4-chloro-6- ({1-[(DIMETHYLAMINO) acetyl] piperidin-4-yl} oxy)-7-methoxyquinazoline (804 mg, 94%). NMR Spectrum : (CDC13) 1.90-2. 15 (m, 4H), 2.29 (s, 6H), 3.15 (s, 2H), 3.60-3. 70 (m, 2H), 3.90 (M, 2H), 4.05 (s, 3H), 4.81 (m, 1H), 7.36 (s, 1H), 7.45 (s, 1H), 8.87 (s, 1H) ; Mass spectrum: MH+ 379.
 

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