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Chemical Structure| 129931-46-0 Chemical Structure| 129931-46-0

Structure of 129931-46-0

Chemical Structure| 129931-46-0

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Product Details of [ 129931-46-0 ]

CAS No. :129931-46-0
Formula : C8H4ClF4NO
M.W : 241.57
SMILES Code : O=C(N)C1=CC(C(F)(F)F)=CC(Cl)=C1F
MDL No. :MFCD01631399

Safety of [ 129931-46-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 129931-46-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 129931-46-0 ]

[ 129931-46-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 129931-46-0 ]
  • [ 129931-47-1 ]
YieldReaction ConditionsOperation in experiment
71% With thionyl chloride; potassium carbonate; In N-methyl-acetamide; EXAMPLE III 3-Chloro-2-fluoro-5-(trifluoromethyl)benzonitrile was prepared as follows: Thionyl chloride, 6.0 g (50 mmol) was added to a slurry of 4.0 g (16 mmol) 3-chloro-2-fluoro-5-(trifluoromethyl) benzamide and 15 mL dimethylformamide at 0 C. After stirring for one hour the reaction mixture was diluted with 25 mL pentane and neutralized by dropwise addition of a saturated potassium carbonate solution and filtered. The pentane solution was dried and distilled to yield 3-chloro-2-fluoro-5-(trifluoromethyl) benzonitrile in 71% yield, bp 75-85 C./20 mm Hg.
 

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