Verteporfin is a YAP inhibitor, which effectively destroys the YAP-TEAD interaction and induces cell apoptosis. At the same time, as an autophagy inhibitor, it specifically blocks the early stage of autophagy by preventing the formation of autophagy. Verteporfin, as a photosensitizer, can generate reactive oxygen species under illumination, and its IC50 value is 0.6nM. Verteporfin has anti-tumor and anti-angiogenesis effects, and can be used for photodynamic therapy and age-related macular degeneration.
Synonyms: CL 318952; BPD-MA; DB00460, CL 318952, BPD-MA, BpdMA, Benzoporphyrin D, Benzoporphyrin derivative monoacid ring A, Verteporfin, Visudyne.
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Akinduro, Oluwaseun O ; Meade, Paola Suarez ; Schiapparelli, Paula ; Whitehead, Rachel ; Tzeng, Stephany Y ; Rosenfeld, Steven S , et al.
Abstract: Chordomas are locally invasive cancers that are highly resistant to radiotherapy. The Brachyury and Yes Associated Protein (YAP) regulatory axis has been implicated as the primary driver of tumorigenicity in chordoma. Here, we aimed to enhance chordoma radiosensitivity by repurposing the FDA-approved YAP inhibitor, Verteporfin. We used five patient-derived chordoma cell lines and generated two YAP1 knockdown cell lines to validate the YAP-targeting phenotype in chordoma. Verteporfin treatment reduced the expression of DNA damage repair proteins and genes. YAP inhibition with either verteporfin or YAP knockdown resulted in enhanced DNA double-stranded breaks after radiation via inhibition of the DNA damage repair pathway and accumulation of cells in the G2M phase. Verteporfin inhibited chordoma tumor growth alone and in combination with radiation in a xenograft mouse model treated with verteporfin loaded microparticles, resulting in sensitization of chordoma tumors to radiation. YAP inhibition with verteporfin renders chordoma more sensitive to radiation via inhibition of the DNA damage repair cascade and accumulation of cells in G2M when they are most susceptible to radiation damage.
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Purchased from AmBeed: 129497-78-5
CAS No. : | 129497-78-5 |
Formula : | C41H42N4O8 |
M.W : | 718.79 |
SMILES Code : | NONE |
Synonyms : |
CL 318952; BPD-MA; DB00460, CL 318952, BPD-MA, BpdMA, Benzoporphyrin D, Benzoporphyrin derivative monoacid ring A, Verteporfin, Visudyne.
|
MDL No. : | MFCD28098202 |
GHS Pictogram: | ![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Target |
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In Vitro:
Concentration | Treated Time | Description | Reference |
hiPSC-CMs | 0.1, 1, 10, 50, 100 μM | 24 h | To pharmacologically inhibit YAP activity and assess its impact on hiPSC-CMs proliferation. Results showed that verteporfin treatment did not significantly reduce hiPSC-CMs proliferation. | PMC7334437 |
Hepa1-6 cells | 0.25 to 1 μM | 48 h | Inhibition of YAP/TEAD complex, reduction of PAI-1 expression and secretion | PMC7583285 |
Sk-Hep1 cells | 0.25 to 1 μM | 48 h | Inhibition of YAP/TEAD complex, reduction of PAI-1 expression and secretion | PMC7583285 |
HEK293A cells | 6.45 µM | 18 h | Inhibition of the YAP-TEAD interaction reduces expression of CAV1 and CAVIN1 | PMC6345631 |
Panc-1 cells | 100 nM | 48 h | To evaluate the effect of Verteporfin on YAP1-TEAD interaction, results showed that Verteporfin significantly reduced the expression of YAP1 target genes. | PMC7017485 |
4T1 TNBC cells | 0.25 μM | 90 min | The combination of PDT with 5-ADC exerted a synergistic cytotoxic effect on 4T1 cells in vitro, significantly reducing cell proliferation and viability. | PMC10664979 |
4T1 TNBC cells | 0.15 μM | 90 min | The combination of PDT with 5-ADC exerted a synergistic cytotoxic effect on 4T1 cells in vitro, significantly reducing cell proliferation and viability. | PMC10664979 |
Huh-7 cells | 1 μM | To validate the sensitivity of Huh-7 cells to Verteporfin after ARID1A silencing, results showed that ARID1A-silenced Huh-7 cells were more sensitive to Verteporfin. | PMC9751287 | |
HLE cells | 1 μM | To validate the sensitivity of HLE cells to Verteporfin after ARID1A silencing, results showed that ARID1A-silenced HLE cells were more sensitive to Verteporfin. | PMC9751287 | |
Huh-7 | 1μM | To validate the sensitivity of ARID1A-silenced cells to Verteporfin. | PMC9751287 | |
HLE | 1μM | To validate the sensitivity of ARID1A-silenced cells to Verteporfin. | PMC9751287 |
In Vivo:
Administration | Dosage | Frequency | Description | Reference |
Balb/c mice | 4T1 breast cancer model | Intravenous injection | 15mg/kg | Single dose, lasting 5 days | The combination of PDT with 5-ADC significantly increased the expression of splenic CD4+ and CD8+ T cells in vivo, suppressing tumor metastasis. | PMC10664979 |
Mice | B16 melanoma model | Intraperitoneal injection | 2 mg/mouse | Every two days | Verteporfin combined with anti-PD-1 antibody or GM-Vac significantly suppressed tumor growth and enhanced the proportion of IFNγ-producing CD8+ and CD4+ T cells in the tumor microenvironment. | PMC6481611 |
Mice | PVR mouse model | Intraperitoneal injection | 100 mg/kg | Every other day for 4 weeks | Verteporfin attenuated the upregulation of Cyclin D1, C-Myc, and Bcl-xl proteins in the PVR mouse model by inhibiting the YAP signaling pathway, indicating its therapeutic potential for PVR. | PMC9344224 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT00211484 | Age-Related Macular Degenerati... More >>ons. Subfoveal Neovascularization. Less << | Phase 2 | Completed | - | United States, New York ... More >> Manhattan Eye, Ear & Throat Hospital New York, New York, United States, 10021 Less << |
NCT02587767 | Acute Central Serous Chorioret... More >>inopathy Less << | Not Applicable | Active, not recruiting | December 2018 | China, Guangdong ... More >> Zhongshan Ophthalmic Center, Sun Yat-sen University Guangzhou, Guangdong, China, 510060 Less << |
NCT02072408 | Polypoidal Choroidal Vasculopa... More >>thy Without Active Polyp Less << | Phase 4 | Completed | - | Korea, Republic of ... More >> Seoul National University Bundang Hospital Seongnam, Gyunggi-do, Korea, Republic of Konyang University Kim's Eye Hospital Seoul, Korea, Republic of Samsung Medical Center Seoul, Korea, Republic of Less << |
NCT00043680 | Macular Degeneration | Phase 2 | Completed | - | United States, Maryland ... More >> National Eye Institute (NEI) Bethesda, Maryland, United States, 20892 Less << |
NCT03497000 | Central Serous Chorioretinopat... More >>hy Tomography, Optical Coherence Less << | Not Applicable | Completed | - | China, Beijing ... More >> People's Hospital of Peking University Beijing, Beijing, China, 100044 Less << |
NCT01162746 | Age-Related Macular Degenerati... More >>on Neovascularization, Choroidal Less << | Phase 2 | Completed | - | Austria ... More >> Department of Ophthalmology, Medical University of Vienna Vienna, Austria, 1090 Less << |
NCT01434095 | Chronic Central Serous Chorior... More >>etinopathy Less << | Not Applicable | Completed | - | Japan ... More >> Department of Ophthalmology, Surugadai Nihon University Hospital Chiyoda-ku, Tokyo, Japan, 101-8309 Less << |
NCT01971190 | Central Serous Chorioretinopat... More >>hy Less << | Phase 2 | Completed | - | Korea, Republic of ... More >> Chungbuk national hospital ChungJu, Korea, Republic of Gangneung asan hospital Gangneung, Korea, Republic of Seoul national university Bundang Hospital Ilsan, Korea, Republic of Asan medical center Seoul, Korea, Republic of, 138736 Kim's Eye Hospital Seoul, Korea, Republic of, 150-034 Samsung seoul hospital Seoul, Korea, Republic of Less << |
NCT00569569 | Age Related Macular Degenerati... More >>on Less << | Phase 2 Phase 3 | Completed | - | - |
NCT00556946 | Port Wine Stains | Not Applicable | Completed | - | United States, California ... More >> Beckman Laser Medical Clinic,University Irvine, California, United States, 02612 Less << |
NCT00556946 | - | Completed | - | - | |
NCT01027468 | Neovascular Age-related Macula... More >>r Degeneration Less << | Not Applicable | Completed | - | - |
NCT01630863 | Central Serous Chorioretinopat... More >>hy Less << | Not Applicable | Unknown | March 2015 | Korea, Republic of ... More >> Yeungnam University College of Medicine Recruiting Daegu, Korea, Republic of Contact: Min Sagong 82-53-620-4191 msagong@ynu.ac.kr Principal Investigator: Min Sagong Less << |
NCT00391144 | Choroidal Neovascularization S... More >>econdary to Pattern Dystrophy Less << | Phase 2 Phase 3 | Unknown | - | Italy ... More >> Clinica Oculistica, Azienda Ospedaliero-Universitaria di Trieste Recruiting Trieste, TS, Italy, 34129 Contact: Giuseppe Ravalico, MD +39 040 772449 giuseppe.ravalico@aots.sanita.fvg.it Less << |
NCT03079141 | Chronic Central Serous Chorior... More >>etinopathy Less << | Phase 4 | Recruiting | February 2021 | Netherlands ... More >> Academic Medical Center Recruiting Amsterdam, Netherlands Contact: Reinier O Schlingemann, MD, PhD Contact: Monique Wezel Leiden University Medical Center Recruiting Leiden, Netherlands Contact: Elon H van Dijk, MD +31715299431 ehcvandijk@lumc.nl Contact: Thomas J van Rijssen, MD t.j.van_rijssen@lumc.nl Radboud University Medical Center Recruiting Nijmegen, Netherlands Contact: Carel B Hoyng, MD, PhD Contact: Asha Kalisingh Less << |
NCT00100009 | Macular Degeneration | Phase 3 | Completed | - | - |
NCT00523406 | Macular Degeneration | Phase 3 | Completed | - | Austria ... More >> Medical University of Vienna, Department of Ophthalmology Vienna, Austria, 1090 Less << |
NCT02452840 | - | Recruiting | October 2022 | United States, North Carolina ... More >> Duke Eye Center Recruiting Durham, North Carolina, United States, 27710 Contact: Ana Garcia-Turner 919-681-8872 Principal Investigator: Scott Cousins, MD Sub-Investigator: Priyatham Mettu, MD Less << | |
NCT00464347 | Age-Related Macular Degenerati... More >>on Less << | Phase 2 | Terminated(Study was terminate... More >>d because of poor enrollment.) Less << | - | United States, Florida ... More >> Retinal Group of Florida Ft. Lauderdale, Florida, United States, 33334 Central Florida Retina- Orlando Orlando, Florida, United States, 32746 Retina Specialists Pensacola, Florida, United States, 32503 United States, Maryland Elman Retina Group- Baltimore Baltimore, Maryland, United States, 21237 United States, Michigan Associated Retinal Consulants Grand Rapids, Michigan, United States, 49546 United States, Minnesota VitroRetinal Surgery Minneapolis, Minnesota, United States, 55435 United States, North Carolina Duke University Eye Center Durham, North Carolina, United States, 27710 United States, South Carolina Palmetto Retina Center Columbia, South Carolina, United States, 29204 United States, Tennessee Southeastern Retina Associates Knoxville, Tennessee, United States, 37909 United States, Texas Texas Retina Associates-Arlington Arlington, Texas, United States, 76012 Texas Retina Associates-Dallas Dallas, Texas, United States, 85231 Less << |
NCT01027468 | - | Completed | - | - | |
NCT00138632 | Wet Age-Related Macular Degene... More >>ration Less << | Phase 1 Phase 2 | Completed | - | United States, California ... More >> Retina-Vitreous Associates Medical Group Beverly Hills, California, United States, 90211 United States, Colorado Porter Adventist Hospital, Eye Lab Denver, Colorado, United States, 80210 United States, Florida USF Eye Institute Tampa, Florida, United States, 33612-4742 United States, Illinois Springfield Clinic, LLP Springfield, Illinois, United States, 62701 United States, Maryland Wilmer Eye Institute Baltimore, Maryland, United States, 21287 United States, Massachusetts Lahey Clinic Medical Center, Eye institute Peabody, Massachusetts, United States, 01960 United States, South Dakota Black Hills Regional Eye Institute Rapid City, South Dakota, United States, 05770 Australia, New South Wales Novartis Investigative Site Parramatta, New South Wales, Australia, 2150 Novartis Investigational Site Sydney, New South Wales, Australia, 2000 Novartis Investigative Site Westmead, New South Wales, Australia, 2145 Australia, Victoria Novartis Investigative Site East Melbourne, Victoria, Australia, 3002 Less << |
NCT00148551 | Age-Related Macular Degenerati... More >>on Less << | Phase 2 Phase 3 | Unknown | March 2008 | Canada, British Columbia ... More >> Eye Care Centre Vancouver, British Columbia, Canada Less << |
NCT02799992 | Chronic Central Serous Chorior... More >>etinopathy Less << | Not Applicable | Unknown | September 2016 | - |
NCT00211419 | Maculopathy, Age-Related | Phase 1 | Completed | - | United States, New York ... More >> Manhattan Eye, Ear & Throat Hospital New York, New York, United States, 10021 Less << |
NCT00211458 | Macular Degeneration | Phase 2 | Completed | - | United States, New York ... More >> Manhattan Eye, Ear & Throat Hospital New York, New York, United States, 10021 Less << |
NCT00527475 | Macular Degeneration | Phase 2 | Completed | - | United States, California ... More >> California Retina Consultants & Research Foundation Santa Barbara, California, United States, 93103 United States, Michigan Associated Retinal Consultants Ann Arbor, Michigan, United States, 49301 United States, Texas Texas Retina Associates Arlington, Texas, United States, 76012 Less << |
NCT00802126 | Myopia | Phase 1 | Completed | - | Italy ... More >> Ophthalmology Department SUN Napoli, Italy, 80100 Less << |
NCT00370539 | Neovascular Age-Related Macula... More >>r Degeneration Less << | Phase 3 | Unknown | - | Iran, Islamic Republic of ... More >> Hamid Ahmadieh, MD Recruiting Tehran, Iran, Islamic Republic of, 16666 Contact: Hamid Ahmadieh, MD +98 21 22585952 hahmadieh@hotmail.com Less << |
NCT01797861 | Chronic Central Serous Chorior... More >>etinopathy Less << | Phase 4 | Completed | - | France ... More >> Creteil University Eye Clinic Paris, France, 94010 Germany Cologne University Eye Clinic Cologne, Germany, 50937 Netherlands Leiden University Medical Center Leiden, Netherlands Radboud University Nijmegen Medical Centre, Institute of Ophthalmology Nijmegen, Netherlands, 6500 HB United Kingdom Oxford University Eye Hospital, John Radcliffe Hospital Oxford, United Kingdom, OX3 9DU Less << |
NCT01482910 | Macular Degeneration | Phase 3 | Completed | - | China, Guangdong ... More >> Guangzhou, Guangdong, China, 510060 China, Hunan Changsha, Hunan, China, 410011 China, Shaanxi Xi'an, Shaanxi, China, 710032 China, Shandong Qingdao, Shandong, China China, Sichuan Chengdu, Sichuan, China, 610041 China, Zhejiang Hangzhou, Zhejiang, China, 310003 Hangzhou, Zhejiang, China, 310009 Wenzhou, Zhejiang, China China Beijing, China, 100044 Beijing, China, 100083 Beijing, China, 100730 Beijing, China, 2000080 Shanghai, China Tianjin, China, 300384 Less << |
NCT01025063 | - | Completed | - | - | |
NCT00002647 | Brain and Central Nervous Syst... More >>em Tumors Metastatic Cancer Less << | Phase 1 | Unknown | - | United States, Wisconsin ... More >> Medical College of Wisconsin Cancer Center Recruiting Milwaukee, Wisconsin, United States, 53226 Contact: Clinical Trials Office - Medical College of Wisconsin Cancer C 414-805-4380 Midwest Children's Cancer Center at Children's Hospital of Wisconsin Recruiting Milwaukee, Wisconsin, United States, 53226 Contact: Bruce A. Kaufman, MD 414-266-2000 Less << |
NCT01482910 | - | Completed | - | - | |
NCT03692169 | - | Recruiting | June 30, 2019 | China, Guangdong ... More >> Fabao Xu Completed Guangzhou, Guangdong, China, 510000 Zhongshan Ophthalmic Center, Sun Yat-sen University Recruiting Guangzhou, Guangdong, China, 510000 Less << | |
NCT00527475 | - | Completed | - | - | |
NCT02081339 | - | Recruiting | March 2024 | Japan ... More >> Kyoto University Graduate School of Medicine Recruiting Kyoto, Japan, 606-8507 Contact: Misao Ogaki +81-75-751-3248 misao@kuhp.kyoto-u.ac.jp Principal Investigator: Akitaka Tsujikawa, MD Less << | |
NCT01256580 | Choroidal Neovascularization ... More >> Myopia Punctate Inner Choroidopathy (PIC) Multifocal Choroiditis Ocular Histoplasmosis Syndrome Central Serous Chorioretinopathy (CSC) Angioid Streaks Trauma, or Hereditary Eye Diseases Less << | Not Applicable | Withdrawn(Lack of eligible sub... More >>jects.) Less << | September 2013 | - |
NCT00967850 | Myopia Choroi... More >>dal Neovascularization Less << | Phase 3 | Completed | - | Spain ... More >> INGO Santiago de Compostela, La Coruña, Spain, 15706 Hospital General Reina Sofía Espinardo, Murcia, Spain, 30100 Clínica Universitaria de Navarra Pamplona, Navarra, Spain, 31080 Instituto Oftalmológico de Alicante Alicante, Spain, 03015 Hospital de la Vall d´Hebron Barcelona, Spain, 08022 Hospital Clínico San Carlos Madrid, Spain, 28010 IOBA - Instituto Universitario de Oftalmobiología Aplicada Valladolid, Spain, 47011 Less << |
NCT00007969 | Melanoma (Skin) | Phase 1 Phase 2 | Completed | - | United States, Colorado ... More >> University of Colorado Cancer Center Denver, Colorado, United States, 80010 United States, Florida Mount Sinai Comprehensive Cancer Center at Aventura Aventura, Florida, United States, 33180 Mount Sinai Comprehensive Cancer Center Miami Beach, Florida, United States, 33140 United States, Michigan Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48201-1379 United States, Missouri Missouri Baptist Cancer Center Saint Louis, Missouri, United States, 63131 United States, Pennsylvania University of Pittsburgh Cancer Institute Pittsburgh, Pennsylvania, United States, 15213-3489 Less << |
NCT00930189 | Subfoveal Choroidal Neovascula... More >>rization Less << | Phase 2 Phase 3 | Unknown | September 2006 | Mexico ... More >> Centro Medico Isemmym Recruiting Metepec, Estado-de-Mexico, Mexico, 52140 Contact: Rosa M Romero, MD 7221600451 rromerocastro@yahoo.com Contact: Hugo Quiroz-Mercado, MD 52555108414000 ext 1171 retinamex@yahoo.com Sub-Investigator: Gerardo Monares, MD Sub-Investigator: Alfredo Morales, MD Sub-Investigator: Juan-Carlos De-la Luz, MD Sub-Investigator: Antonio Niño, MD Sub-Investigator: Gonzalo Padilla, MD Sub-Investigator: Hugo Quiroz-Mercado, MD Less << |
NCT02120950 | Neovascular Macular Degenerati... More >>on Less << | Phase 4 | Active, not recruiting | July 2017 | - |
NCT00390208 | Age Related Macular Degenerati... More >>on Less << | Phase 2 | Completed | - | United States, California ... More >> Bay Area Retina Associates Castro Valley, California, United States, 94546 Bay Area Retina Associates Walnut Creek, California, United States, 94598 United States, Georgia Georgia Retina Riverdale, Georgia, United States, 30274 United States, Ohio Retina Vitreous Associates Toledo, Ohio, United States, 43608 Less << |
NCT00457678 | Age Related Macular Degenerati... More >>on Less << | Phase 2 | Withdrawn(Site did not enroll ... More >>any patients to the study.) Less << | - | - |
NCT00813891 | Macular Degeneration ... More >> Visual Acuity Less << | Phase 4 | Unknown | December 2009 | Canada, Quebec ... More >> The Royal Victoria Hospital and the Montreal Retinal Institute Not yet recruiting Montreal, Quebec, Canada, H3Z 1P4 Less << |
NCT00726973 | Macular Edema | Not Applicable | Withdrawn(Unable to recruit st... More >>udy participants) Less << | July 2012 | - |
NCT01032109 | Age-related Macular Degenerati... More >>on Less << | Not Applicable | Completed | - | Japan ... More >> Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences, Kumamoto University Kumamoto, Japan, 860-8556 Less << |
NCT00331435 | Age Related Macular Degenerati... More >>on Less << | Phase 4 | Completed | - | Japan ... More >> Nagoya City University Hospital Aichi, Japan Nagoya University Aichi, Japan Kyushu University Fukuoka, Japan, 812-0054 Fukushima Medical University School of Medicine Fukushima, Japan, 960-1295 Gunma University Gunma, Japan Kagawa University Kagawa, Japan, 761-0793 Kyoto University Kyoto, Japan, 606-8507 Osaka University Osaka, Japan, 565-0871 Kansai Medical University Takii Hospital Osaka, Japan, 570-8507 Kansai Medical University Hirakata Hospital Osaka, Japan, 573-1191 Sapporo City general hospital Sapporo, Japan, 060-8604 Shiga University of Medical Science Shiga, Japan Surugadai Nihon University Hospital Tokyo, Japan, 101-8309 Kyorin University Tokyo, Japan, 181-8611 Toho University Tokyo, Japan Tokyo University Ohashi Medical Center Tokyo, Japan Yamanashi University Yamanashi, Japan Less << |
NCT00696592 | Neovascular Age-Related Macula... More >>r Degeneration Less << | Phase 2 | Unknown | - | Italy ... More >> Department of Ophthalmology, University of Padova Recruiting Padova, PD, Italy, 35100 Contact: Giuseppe Lo Giudice, M.D. 0039049 2050153 gvofta@libero.it Principal Investigator: Stefano Piermarocchi, M.D. Less << |
NCT01666236 | Choroidal Neovascularization ... More >> Retinal Pigment Epithelial Detachment Less << | Phase 4 | Withdrawn(Lack of resources) | September 2014 | Brazil ... More >> Universidade Federal de São Paulo - Escola Paulista de Medicina São Paulo, SP, Brazil, 04038-034 Less << |
NCT00347399 | Age Related Macular Degenerati... More >>on Less << | Phase 2 | Unknown | - | Mexico ... More >> Hospital Luis Sanchez Bulnes Recruiting Mexico city, DF, Mexico, 04030 Contact: Hugo Quiroz-Mercado, MD 525510841400 retinamex@yahoo.com Principal Investigator: Maura L Abraham Marin, MD Less << |
NCT00413829 | Age Related Macular Degenerati... More >>on Less << | Phase 2 | Completed | - | Switzerland ... More >> Klinik und Poliklinik fuer Augenheilkunde, Inselspital Bern, Switzerland Less << |
NCT01574430 | Central Serous Chorioretinopat... More >>hy Less << | Phase 4 | Completed | - | China, Beijing ... More >> People's Hospital of Peking University Beijing, Beijing, China, 100044 Less << |
NCT02464761 | Vertebral Metastases | Phase 1 | Completed | - | Canada, Ontario ... More >> Sunnybrook Health Sciences Centre Toronto, Ontario, Canada, M4N 3M5 Less << |
NCT00056823 | Age-Related Maculopathy | Phase 1 Phase 2 | Completed | - | - |
NCT02321267 | Macular Disease | Phase 4 | Recruiting | December 2024 | Japan ... More >> Kagawa University Faculty of Medicine Recruiting Miki, Kagawa, Japan, 761-0793 Contact +81878912211 chosa@med.kagawa-u.ac.jp Less << |
NCT01746875 | Macular Degeneration ... More >> Retinal Detachment Less << | Not Applicable | Terminated(treatment effects n... More >>ot as desired) Less << | - | Norway ... More >> Department of Neuroscience, NTNU Trondheim, Norway, 7489 Less << |
NCT00041483 | Macular Degeneration | Phase 3 | Completed | - | United States, Texas ... More >> Contact Alcon Call Center for Trial Locations Ft. Worth, Texas, United States, 76134 Less << |
NCT00546936 | Presumed Ocular Histoplasmosis... More >> (POHS) Less << | Phase 2 | Unknown | April 2010 | United States, Indiana ... More >> Macula-Retina-Vitreous Service, Midwest Eye Institute Recruiting Indianapolis, Indiana, United States, 46280 Contact: Neelam Thukral 317-805-2152 neelamt@midwest.com Principal Investigator: Thomas Ciulla, MD United States, Missouri Barnes Retina Institute Recruiting St. Louis, Missouri, United States, 63110 Contact: Ginny S Nobel, COT 314-367-1278 ext 2305 bristudy@barnesretinainstitute.com Contact: Carol L Walters, COT 314-367-2287 ext 2312 bristudy@barnesretinainstitute.com Principal Investigator: Kevin J Blinder, MD Less << |
NCT02457026 | Neovascular Age-related Macula... More >>r Degeneration Less << | Not Applicable | Withdrawn | January 2018 | United States, North Carolina ... More >> Duke Eye Center Durham, North Carolina, United States, 27710 Less << |
NCT01325181 | Chronic Central Serous Chorior... More >>etinopathy Less << | Phase 1 Phase 2 | Completed | - | Korea, Republic of ... More >> • Department of Ophthalmology, Seoul National University College of Medicine Seoul, Gyeonggi-do, Korea, Republic of Less << |
NCT01360151 | Polypoidal Choroidal Vasculopa... More >>thy Less << | Not Applicable | Unknown | May 2011 | Korea, Republic of ... More >> Won Ki Lee Recruiting Seoul, Korea, Republic of Contact: Won Ki Lee, MD, PhD 82-2-10-3265-1262 wklee@catholic.ac.kr Contact: Mee Yon Lee, MD 82-10-3230-1863 deenie@daum.net Less << |
NCT03459144 | Polypoidal Choroidal Vasculopa... More >>thy Less << | Not Applicable | Completed | - | China, Guangdong ... More >> Zhongshan Ophthalmic Center Guangzhou, Guangdong, China, 510060 Less << |
NCT01325181 | - | Completed | - | - | |
NCT02495181 | Polypoidal Choroidal Vasculopa... More >>thy Less << | Phase 4 | Recruiting | March 2020 | Portugal ... More >> Hospital de Braga Recruiting Braga, Portugal, 4710-243 Contact: Luís Mendonça Hospital de Braga Recruiting Braga, Portugal Contact: Luís Mendonça luismendonc@gmail.com AIBILI - Centro de Ensaios Clínicos Recruiting Coimbra, Portugal, 3000-548 Coimbra Contact: Rufino Silva Espaço Médico de Coimbra Recruiting Coimbra, Portugal, 3030-163 Contact: João Figueira Centro Hospitalar de Leiria Recruiting Leiria, Portugal, 2400-171 Contact: João Paulo Castro Sousa IRL - Instituto de Retina e Diabetes de Lisboa Recruiting Lisboa, Portugal, 1050-085 Lisboa Contact: Paulo Rosa Instituto de Microcirurgia Ocular Recruiting Lisboa, Portugal, 1600-209 Contact: José Roque Centro Hospitgalar de Lisboa Norte, EPE - Hospital de Santa Maria Recruiting Lisboa, Portugal, 1649-035 Contact: Sara Vaz-Pereira Hospital de Vila Franca de Xira - Serviço de Oftalmologia Recruiting Lisboa, Portugal, 2600-009 Contact: Miguel Amaro Instituto de Oftalmologia Dr. Gama Pinto Recruiting Lisboa, Portugal Contact: Victor Ágoas vagoas@igpinto.min-saude.pt Centro Hospitalar do Porto- Hospital de Santo António Recruiting Porto, Portugal, 4099-001 Contact: Angelina Meireles Centro Hospitalar de São João, EPE - Serviço de Oftalmologia Recruiting Porto, Portugal, 4200-319 Contact: ângela Carneiro Spain Unidade Clinica de Retina Recruiting Albacete, Spain Contact: Carlos Cava ccavavalenciano@yahoo.es Bellvitge University Hospital Recruiting Barcelona, Spain Contact: Luis Arias luisariasbarquet@gmail.com Centro de Oftalmología Barraquer Recruiting Barcelona, Spain Contact: Sonia Viver docsonia@barraquer.com Instituto de Microcirugia Ocular Recruiting Barcelona, Spain Contact: Anniken Bures bures@imo.es Vall d'Hebron Hospital Recruiting Barcelona, Spain Contact: Laura Distefano laura.distefano@outlook.com Hospital Insular de Gran Canaria Recruiting Las Palmas, Spain Contact: Francisco Cabrera López Instituto Oftalmológico Fernandez-Vega Recruiting Oviedo, Spain Contact: Alvaro Fernandez-Vega Sanz Vega Sanz investigacion@fernandez-vega.com Less << |
NCT00423189 | Age-Related Macular Degenerati... More >>on Less << | Phase 4 | Terminated(Lack of efficacy) | - | United States, Texas ... More >> Vitreoretinal Consultants Houston, Texas, United States, 77030 Less << |
NCT00061594 | Macular Degeneration | Phase 3 | Completed | - | - |
NCT00094120 | Macular Degeneration | Phase 2 | Terminated | - | United States, Pennsylvania ... More >> Genaera Corporation Plymouth Meeting, Pennsylvania, United States, 19462 Less << |
NCT00455871 | Age-Related Macular Degenerati... More >>on Less << | Not Applicable | Unknown | October 2010 | United States, Missouri ... More >> Barnes Retina Institute Recruiting St. Louis, Missouri, United States, 63110 Principal Investigator: Gaurav K Shah, MD Less << |
NCT00570193 | Choroidal Neovascularization ... More >> Macular Degeneration Less << | Phase 1 Phase 2 | Completed | - | - |
NCT00211445 | Chronic Central Serous Chorior... More >>etinopathy Less << | Phase 2 | Completed | - | United States, New York ... More >> Manhattan Eye, Ear & Throat Hospital New York, New York, United States, 10021 Less << |
NCT02702700 | Pleural Effusion, Malignant | Phase 1 | Recruiting | June 2019 | Switzerland ... More >> Oncology Department, Centre Hospitalier Universitaire Vaudois (CHUV) Recruiting Lausanne, Vaud (VD), Switzerland, 1011 Contact: Solange Peters, MD-PhD +41 21 314 44 62 solange.peters@chuv.ch Less << |
NCT01217944 | Pathological Myopia | Phase 3 | Completed | - | - |
NCT00140803 | Age-Related Macular Degenerati... More >>on Less << | Phase 2 | Completed | - | United States, New York ... More >> Manhattan Eye, Ear & Throat Hospital New York, New York, United States, 10021 Canada, British Columbia Vh/UBC Eye Care Centre Vancouver, British Columbia, Canada, V5Z 3N9 Less << |
NCT00135837 | Age-Related Macular Degenerati... More >>on Less << | Phase 4 | Completed | - | Switzerland ... More >> Novartis Basel, Switzerland Less << |
NCT00680498 | Age-Related Macular Degenerati... More >>on Less << | Phase 4 | Completed | - | United States, Illinois ... More >> Illinois Retina Associates Oak Park, Illinois, United States, 60304 Less << |
NCT01217944 | - | Completed | - | - | |
NCT03033225 | Pancreatic Cancer Non-Resectab... More >>le Less << | Phase 2 | Recruiting | January 2022 | United States, Florida ... More >> Mayo Clinic in Florida Recruiting Jacksonville, Florida, United States, 32224 Contact: Betsy Cayer cayer.frances@mayo.edu United States, Minnesota Mayo Clinic in Rochester Recruiting Rochester, Minnesota, United States, 55905 Contact: Lori S Lutzke 507-255-7495 lutzke.lori@mayo.edu Contact: James Allen Allen.James1@mayo.edu Less << |
NCT00390026 | Age-Related Macular Degenerati... More >>on Less << | Phase 3 | Withdrawn(Lucentis, a treatmen... More >>t superior to PDT, has become available i Sweden.) Less << | - | Sweden ... More >> S:t Eriks Eye Hospital Stockholm, Sweden, SE-11282 Less << |
NCT00471406 | Corneal Neovascularization | Not Applicable | Completed | - | - |
NCT00492284 | - | Completed | - | - | |
NCT00288561 | Age-Related Macular Degenerati... More >>on (ARMD) Less << | Phase 2 | Completed | - | Switzerland ... More >> Novartis Basel, Switzerland Less << |
NCT00121407 | Macular Degeneration | Phase 3 | Completed | - | - |
NCT00492284 | Choroidal Neovascularization ... More >> Macular Degeneration Less << | Phase 2 | Completed | - | - |
NCT01570608 | Age Related Macular Degenerati... More >>on Less << | Phase 3 | Completed | - | Austria ... More >> Department of OPhthalmology Medical center east Vienna, Austria, A1030 Department of Ophthalmology Rudolf foundation Clinic Vienna, Austria, A1030 Department of Ophthalmology, Hospital Hietzing Vienna, Austria, A1030 Less << |
NCT02821520 | Polypoidal Choroidal Vasculopa... More >>thy Less << | Phase 4 | Recruiting | December 2019 | China, Zhejiang ... More >> The Eye Hospital of Wenzhou Medical University Recruiting Wenzhou, Zhejiang, China, 325000 Contact: Zuhua Sun, master 86-577-88068855 susan0402@163.com Principal Investigator: Xiaoling Liu, professor Less << |
NCT02939274 | Metastatic Breast Cancer | Phase 2 | Recruiting | December 2019 | United States, Massachusetts ... More >> Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Steven J Isakoff, MD PhD 617-726-4920 Dana Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Beth Overmoyer, MD 617-632-3800 Less << |
NCT00134667 | Age-Related Macular Degenerati... More >>on Less << | Phase 4 | Terminated | - | United States, Arizona ... More >> Retina Centers, P.C., Northwest Location Tucson, Arizona, United States, 85704-5614 Less << |
NCT00426998 | Choroidal Neovascularization ... More >> Macular Degeneration Less << | Phase 2 | Completed | - | United States, California ... More >> Retinal Consultants Medical Group, Inc. Sacramento, California, United States, 95819 Less << |
NCT00423189 | - | Terminated(Lack of efficacy) | - | - | |
NCT01019668 | Central Serous Chorioretinopat... More >>hy Less << | Not Applicable | Completed | - | Taiwan ... More >> Shin Kong Wu Ho-Su Memorial Hospital Taipei, Taiwan, 111 Less << |
NCT01968486 | Myopia, Degenerative | Phase 1 | Completed | - | - |
NCT00403442 | Macular Degeneration | Phase 1 | Terminated | - | United States, New York ... More >> Vitreous Retina Macula Consultants of New York, P.C. New York, New York, United States, 10022 Less << |
NCT00049959 | Basal Cell Carcinoma ... More >> Nevoid Basal Cell Carcinoma Syndrome Gorlin Syndrome Less << | Phase 3 | Terminated | - | - |
NCT00242580 | Macular Degeneration ... More >> Choroidal Neovascularization Less << | Phase 3 | Completed | - | United States, Texas ... More >> Novartis Investigational Site Austin, Texas, United States, 78793 Less << |
NCT00429962 | Choroidal Neovascularization ... More >> Age-Related Macular Degeneration Less << | Phase 3 | Completed | - | Switzerland ... More >> University Eye Clinic Basel, Basel-Stadt, Switzerland, 4031 Less << |
NCT00242580 | - | Completed | - | - | |
NCT01974622 | Retinal Vascular Disorders | Not Applicable | Unknown | June 2015 | United States, New York ... More >> Vitreous Retina Macula Consultants of New York Recruiting New York, New York, United States, 10022 Contact: Lawrence A. Yannuzzi, M.D. 212-605-3777 layannuzzi@gmail.com Contact: Irene Barbazetto, M.D. (212) 861-9797 ibarbazetto@gmail.com Principal Investigator: Lawrence A. Yannuzzi, M.D. Sub-Investigator: Irene Barbazetto, M.D. Less << |
NCT00473642 | Age-Related Maculopathy ... More >> Choroidal Neovascularization Less << | Phase 4 | Completed | - | United States, Oklahoma ... More >> Eagle Mountain Vision Tulsa, Oklahoma, United States, 74132 Less << |
NCT00473642 | - | Completed | - | - | |
NCT01922102 | Visual Impairment Due to Choro... More >>idal Neovascularization Secondary to Pathologic Myopia Less << | Phase 3 | Completed | - | - |
NCT00729846 | - | Completed | - | - | |
NCT00729846 | Age Related Macular Degenerati... More >>on Choroidal Neovascularization Macular Edema Less << | Phase 2 | Completed | - | United States, California ... More >> California Retina Consultants Bakersfield, California, United States, 93309 California Retina Consultants Santa Barbara, California, United States, 93103 Less << |
NCT00967213 | Neovascular Age-related Macula... More >>r Degeneration Less << | Phase 3 | Completed | - | Korea, Republic of ... More >> Dept. of Ophthalmology, KyungHee Medical Center, #1 Hoegi, Dongdaemun-gu Seoul, Korea, Republic of, 130-702 Less << |
NCT00359164 | Macular Degeneration | Phase 2 | Completed | - | Canada, British Columbia ... More >> Vancouver General Hospital Eye Care Centre (UBC) Vancouver, British Columbia, Canada, V5Z 3N9 Less << |
NCT00436553 | Macular Degeneration ... More >> Choroidal Neovascularization Less << | Phase 3 | Completed | - | - |
NCT01846273 | Age-related Macular Degenerati... More >>on Polypoidal Choroidal Vasculopathy PCV Less << | Phase 4 | Completed | - | - |
NCT00436553 | - | Completed | - | - | |
NCT00433017 | Macular Degeneration ... More >> Choroidal Neovascularization Less << | Phase 2 Phase 3 | Terminated(Study was terminate... More >>d based on the results of analyses performed as planned at Month 12.) Less << | - | Austria ... More >> Novartis Investigative site Wien, Austria Belgium Novartis Investigative site Antwerpen, Belgium Denmark Novartis Investigative site Aalborg, Denmark France Novartis Investigative site Creteil, France Germany Novartis Investigative site Regensburg, Germany Hungary Novartis Investigative site Budapest, Hungary Italy Novartis Investigative site Firenze, Italy Netherlands Novartis Investigative site Rotterdam, Netherlands Poland Novartis Investigative site Warszawa, Poland Spain Novartis Investigative site Madrid, Spain Switzerland Novartis Investigative site Geneve, Switzerland United Kingdom Novartis Investigative site Manchester, United Kingdom Less << |
NCT00574093 | Neovascular Age Related Macula... More >>r Degeneration Less << | Phase 2 | Completed | - | Italy ... More >> Fondazione G.B.Bietti-IRCCS Rome, Italy, 00198 Less << |
NCT00674323 | Polypoidal Choroidal Vasculopa... More >>thy Less << | Phase 4 | Completed | - | Hong Kong ... More >> Novartis Investigative Site Hong Kong, Hong Kong Korea, Republic of Novartis Investigative Site Seoul, Korea, Republic of Singapore Novartis Investigative Site Singapore, Singapore Taiwan Novartis Investigative Site Taipei, Taiwan Thailand Novartis Investigative Site Bangkok, Thailand Less << |
NCT00674323 | - | Completed | - | - | |
NCT02872064 | Breast Neoplasms | COMPLETED | 2025-12-17 | Royal Free Hospital, London, N... More >>W3 2QG, United Kingdom Less << | |
NCT03067051 | Recurrent Prostate Cancer | Phase 1 | Recruiting | December 31, 2020 | United States, Pennsylvania ... More >> Keith Cengel Not yet recruiting Philadelphia, Pennsylvania, United States, 19104-6205 Contact: Keith Cengel, MD Contact: Sally Mcnulty, RN Canada, Ontario Princess Margaret Cancer Centre Recruiting Toronto, Ontario, Canada, ON M5G 2M9 Contact: Neil Fleshner, MD United Kingdom Reader in Urology, University College London & Honorary Consultant Urological Surgeon, University College London Hospitals Trust Recruiting London, United Kingdom, W1W 7TS Contact: Caroline Moore, MD Contact: Rebecca Scott, RN Less << |
NCT00433017 | - | Terminated(Study was terminate... More >>d based on the results of analyses performed as planned at Month 12.) Less << | - | - | |
NCT05589974 | Central Serous Chorioretinopat... More >>hy Less << | RECRUITING | 2026-07-31 | Stavanger University Hospital,... More >> Department of Ophthalmology, Stavanger, 4016, Norway Less << | |
NCT04590664 | Glioblastoma|Recurrent Gliobla... More >>stoma Less << | PHASE1|PHASE2 | RECRUITING | 2025-08-15 | Emory University Hospital/Wins... More >>hip Cancer Institute, Atlanta, Georgia, 30322, United States Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() | 1mg | 5mg | 10mg |
1 mM 5 mM 10 mM | 1.39mL 0.28mL 0.14mL | 6.96mL 1.39mL 0.70mL | 13.91mL 2.78mL 1.39mL |