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Chemical Structure| 1286202-05-8 Chemical Structure| 1286202-05-8

Structure of 1286202-05-8

Chemical Structure| 1286202-05-8

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Product Details of [ 1286202-05-8 ]

CAS No. :1286202-05-8
Formula : C14H18BN3O2
M.W : 271.12
SMILES Code : CC1(C)OB(C2=CN(C3=CC=CN=C3)N=C2)OC1(C)C
MDL No. :MFCD21099734
InChI Key :DMXSOTHMZWWOPT-UHFFFAOYSA-N
Pubchem ID :57416218

Safety of [ 1286202-05-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 1286202-05-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1286202-05-8 ]

[ 1286202-05-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 856013-04-2 ]
  • [ 1286202-05-8 ]
  • [ 1353560-13-0 ]
YieldReaction ConditionsOperation in experiment
97% With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In water; acetonitrile; at 70℃; for 18h;Inert atmosphere; Under argon, 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]pyridine (0.2 g, 0.74 mmol, prepared by the methods described in WO 2011/045224), 6-bromopyridin-2-sulphonamide (0.175 g, 0.74 mmol) and tetrakis(triphenylphosphine)palladium (0.025 g, 0.022 mmol) were added to a mixture, degassed by means of argon, of sodium carbonate solution in water (2.9 ml, 2 M/L) and acetonitrile (4 ml). The reaction mixture was stirred at 70 C. for 18 h. After cooling, the reaction mixture was poured onto water and the precipitated crystals were filtered off with suction. They were subsequently stirred with diethyl ether and filtered off with suction. This gave 0.23 g (97% of theory) of 6-[1-(pyridin-3-yl)-1H-pyrazol-4-yl]pyridine-2-sulphonamide.HPLC-MS: LogP(HCOOH): 0.99; mass (m/z): 302.1 (M+H)+ 1H NMR (d6-DMSO): 7.43 (s, 2H), 7.60-7.63 (m, 1H), 7.76 (d, 1H), 8.00 (d, 1H), 8.11 (t, 1H), 8.28-8.31 (m, 1H), 8.53 (s, 1H), 8.58-8.60 (m, 1H), 9.16-9.17 (m, 1H), 9.33 (s, 1H) ppm
 

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