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Chemical Structure| 128372-77-0 Chemical Structure| 128372-77-0

Structure of 128372-77-0

Chemical Structure| 128372-77-0

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Product Details of [ 128372-77-0 ]

CAS No. :128372-77-0
Formula : C10H17NO3
M.W : 199.25
SMILES Code : O=C(N1C(C)CCC1=O)OC(C)(C)C
MDL No. :MFCD24466295

Safety of [ 128372-77-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 128372-77-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 128372-77-0 ]

[ 128372-77-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 450-90-8 ]
  • [ 128372-77-0 ]
  • tert-butyl N-[5-(4-fluoro-2-methoxyphenyl)-5-oxopentan-2-yl]carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With isopropylmagnesium bromide; In tetrahydrofuran; hexane; at 20℃; for 19h;Inert atmosphere; Add dry THF (20mL) to a reaction flask containing SM 69 (2.52g, 10mmol), under nitrogen protection, and add isopropyl magnesium bromide (10mL, 1M in Hexane) to the flask under ice-water bath conditions,Then remove the ice water bath and stir at room temperature for 7 hours,Finally, tert-butyl 2-methyl-5-oxopyrrolidine-1-carboxylate (1.99 g, 10 mmol) was added and reacted at room temperature for 12 hours. Pour the reaction solution into saturated aqueous ammonium chloride solution,Extract with 30mL (10mL×3) ethyl acetate,Combine the organic phases, dry with anhydrous sodium sulfate,After purification by column chromatography, Int 337-1 (2.28 g, 7 mmol) was obtained with a yield of 70%.
 

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