Alternatived Products of [ 127783-73-7 ] Product Details of [ 127783-73-7 ]
CAS No. : | 127783-73-7 | MDL No. : | MFCD06204112 |
Formula : |
C15H11F3O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : |
280.24
| Pubchem ID : | - |
Synonyms : | |
Safety of [ 127783-73-7 ]
Signal Word: | | Class: | |
Precautionary Statements: | | UN#: | |
Hazard Statements: | | Packing Group: | |
Application In Synthesis of [ 127783-73-7 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 127783-73-7 ]
- 1
- [ 127783-73-7 ]
- [ 457889-46-2 ]
Yield | Reaction Conditions | Operation in experiment |
93% | | Example 107; 3-{4-[1-(4'-Trifluoromethyl-biphenyl-4-ylmethyl)-propoxy]-benzoylamino}- propionic acid; Step A. (4'-Trifluoromethyl-biphenyl-4-yl)-methanol; To a solution of 4'-trifluoromethyl-biphenyl-4-carboxylic acid methyl ester (3.71g, 13.3mmol) in tetrahydro-furan (30mL) is added lithium aluminum hydride (14.6 mmol, 1.0 M in tetrahydro-furan) at 0 C under inert atmosphere of nitrogen. After the reaction is stirred at 0 C for 10 minutes following completion of hydride addition, it is quenched with ethyl acetate (lOmL) followed by potassium hydrogen sulfate (1.0 M, 15mmol) slowly at 0 C, diluted mixture with ethyl ether and filtered. Organic layers are washed with brine, dried over sodium sulfate, filtered, and then concentrated under reduced pressure. Column chromatography (silica gel) with 20-80% ethyl acetate/hexane gradient gives 3.1g (12.3mmol, 93%) of title compound. |
- 2
- [ 588-72-7 ]
- [ 455-13-0 ]
- C26H31IN2NiO2 [ No CAS ]
- [ 127783-73-7 ]
- [ 581-80-6 ]
- [ 1149-56-0 ]
- [ 792-74-5 ]
- [ 1149-18-4 ]