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Chemical Structure| 127199-55-7 Chemical Structure| 127199-55-7

Structure of 127199-55-7

Chemical Structure| 127199-55-7

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Product Details of [ 127199-55-7 ]

CAS No. :127199-55-7
Formula : C10H20N2O2
M.W : 200.28
SMILES Code : O=C(OC(C)(C)C)N[C@H]1CNC[C@H]1C
MDL No. :MFCD18432661

Safety of [ 127199-55-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 127199-55-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 127199-55-7 ]

[ 127199-55-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1239460-75-3 ]
  • [ 127199-55-7 ]
  • tert-butyl N-[(3R,4R)-4-methyl-1-[8-(trifluoromethyl)quinolin-5-yl]pyrrolidin-3-yl]carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
85% With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; potassium phosphate; DavePhos; In N,N-dimethyl-formamide; at 130℃; for 3.0h;Inert atmosphere; tert-butyl N-[(3R,4R)-4-methyl-1-[8-(trifluoromethyl)quinolin-5-yl]pyrrolidin-3-yl]carbamate To a solution of <strong>[1239460-75-3]5-bromo-8-(trifluoromethyl)quinoline</strong> (245 mg, 0.89 mmol) in N,N-dimethylformamide (5 mL) was added tert-butyl N-[(3R,4R)-4-methylpyrrolidin-3-yl]carbamate (241 mg, 1.20 mmol), Pd2(dba)3.CHCl3 (124 mg, 0.12 mmol), K3PO4 (768 mg, 3.62 mmol) and DavePhos (93 mg, 0.23 mmol) at the room temperature. The resulting mixture was stirred for 3 h at 130 C. When the reaction was done, the solids in the reaction mixture were filtered out, and the filtrate was diluted by water (20 mL). The resulting mixture was extracted with DCM (50 mL*3). The organic phases were combined, washed with brine and dried over Na2SO4. The solution was removed under reduced pressure and the residue was purified by flash chromatography eluting with EtOAc in hexane (0% to 20% gradient) to yield tert-butyl N-[(3R,4R)-4-methyl-1-[8-(trifluoromethyl)quinolin-5-yl]pyrrolidin-3-yl]carbamate as brown solid (298 mg, 85%). MS: m/z=396.2 [M+H]+.
 

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