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Chemical Structure| 1270019-92-5 Chemical Structure| 1270019-92-5

Structure of 1270019-92-5

Chemical Structure| 1270019-92-5

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Product Details of [ 1270019-92-5 ]

CAS No. :1270019-92-5
Formula : C11H22N2O2
M.W : 214.30
SMILES Code : O=C(OC(C)(C)C)N[C@H]1CNC[C@@H](C)C1
MDL No. :MFCD18071731
InChI Key :CNALVHVMBXLLIY-DTWKUNHWSA-N
Pubchem ID :58386822

Safety of [ 1270019-92-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1270019-92-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1270019-92-5 ]

[ 1270019-92-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1239460-75-3 ]
  • [ 1270019-92-5 ]
  • tert-butyl N-[(3R,5S)-5-methyl-1-[8-(trifluoromethyl)quinolin-5-yl]piperidin-3-yl]carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
77% With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; potassium phosphate; DavePhos; In N,N-dimethyl-formamide; at 130℃; for 3.0h; At room temperature, to a solution of <strong>[1239460-75-3]5-bromo-8-(trifluoromethyl)quinoline</strong> (950mg, 3.44 minol) in DMF (10 mL) was added tert-butyl N-[(3R,5S)-5-methylpiperidin-3- yljcarbamate (718 mg, 3.35 mol), K3P04 (2.19 g, 10.29 minol), Pd2(dba)3CHC13 (356 mg, 0.34 minol) and DavePhos (270 mg, 0.69 minol). The resultingminxture was heated to 130 C and stirred for 3 h. After cooling to room temperature, the reactionminxture was diluted with water (10 mL). The resultingminxture was extracted with ethyl acetate (20 mL x 3). The organic phases were combined, washed with brine and dried over Na2SO4. The solvent was removed under reduced pressure and the residue was purified by flash chromatography eluting with EtOAc in hexane (0% to 14% gradient) to yield tert-butyl N- [(3R,5S )-5-methyl- 1- [8-(trifluoromethyl)quinolin-5- yljpiperidin-3-yljcarbamate as yellow solid (1.10 g, 77%). MS: m/z = 410.2 [M+Hj.
 

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