126917-10-0|2-Fluoro-4-(trifluoromethyl)benzoyl chloride| Ambeed

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Quality Control of [ 126917-10-0 ] Purity: 98% SDS Specification

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Product Details of [ 126917-10-0 ]

CAS No. :	126917-10-0
Formula :	C₈H₃ClF₄O
M.W :	226.56
SMILES Code :	O=C(Cl)C1=CC=C(C(F)(F)F)C=C1F
MDL No. :	MFCD00061155
InChI Key :	OOAHPLWBUUTFMV-UHFFFAOYSA-N
Pubchem ID :	145580

Safety of [ 126917-10-0 ]

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H314
Precautionary Statements:	P280-P305+P351+P338-P310
Class:	8
UN#:	3265
Packing Group:	Ⅱ

Application In Synthesis of [ 126917-10-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 126917-10-0 ]

[ 126917-10-0 ] Synthesis Path-Downstream 1~1

1
[ 937602-15-8 ]
[ 126917-10-0 ]
2-fluoro-N-methyl-4-(trifluoromethyl)-N-(5-(trifluoromethyl)pyridin-2-yl)benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
47%	With dmap; triethylamine; In tetrahydrofuran; at 20℃; for 3h;Cooling with ice;	Example 1-1 (0142) Production Method of 2-fluoro-N-methyl-4-(trifluoromethyl)-N-(5-(trifluoromethyl)pyridin-2-yl)benzamide (0143) 2-Fluoro-4-trifluoromethyl benzoyl chloride (409 mg) and a THF (1 mL) solution were added to a mixture of <strong>[937602-15-8]N-methyl-5-(trifluoromethyl)pyridin-2-amine</strong> (264 mg), THF (4 mL) and triethylamine (1 mL) under ice cooling. After heating to room temperature, N,N-dimethyl aminopyridine (50 mg) was added, and the resulting mixture was stirred for 3 hours. Water was added to the reaction mixture, and extraction with ethyl acetate was performed. The organic layer was dried over anhydrous magnesium sulfate and then concentrated in vacuo. The resulting residue was subjected to column chromatography to give the desired compound (260 mg, yield: 47%).

References: [1]Patent: US2016/366884,2016,A1 .Location in patent: Paragraph 0142; 0143.

Historical Records

Technical Information

• Acyl Group Substitution • Alkyl Halide Occurrence • Catalytic Hydrogenation • Complex Metal Hydride Reductions • General Reactivity • Grignard Reaction • Hiyama Cross-Coupling Reaction • Hydride Reductions • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Preparation of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Rosenmund Reduction • Specialized Acylation Reagents-Ketenes • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling

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[ 126917-10-0 ]

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CAS No.: 126917-10-0

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