Home Cart Sign in  
Chemical Structure| 1265355-07-4 Chemical Structure| 1265355-07-4

Structure of 1265355-07-4

Chemical Structure| 1265355-07-4

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1265355-07-4 ]

CAS No. :1265355-07-4
Formula : C12H15BO5
M.W : 250.06
SMILES Code : O=C(OCC)CC1C2=C(C)C=C(O)C=C2B(O)O1

Safety of [ 1265355-07-4 ]

Application In Synthesis of [ 1265355-07-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1265355-07-4 ]

[ 1265355-07-4 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 1265355-07-4 ]
  • [ 3034-48-8 ]
  • [ 1265362-49-9 ]
YieldReaction ConditionsOperation in experiment
G121: 2-(l-Hvdroxy-4-methyl-6-(5-nitrothiazol-2-yloxy)-l,3- dihvdrobenzofcJfl,2Joxaborol-3-yl)acetic acid[0663] To a solution of ethyl 2-(l ,6-dihydroxy-4-methyl- 1 ,3-dihydrobenzo[c] [ 1 ,2] oxaborol-3-yl)acetate (2.5g, 10 mmol) in anhydrous DMF (40 mL) was added Cs2CO3 (6.5g, 20mmol) and <strong>[3034-48-8]<strong>[3034-48-8]2-bromo-5-nitrothiazol</strong>e</strong> (2.09g, lOmmol) at 0 0C. After stirring for 15 min at room temperature, the resulting mixture was stirred at 55 0C overnight. The reaction quenched by adding cold brine at 0 0C and the mixture was acidified to pH 7 using IN HCl. The resulting mixture was extract with EtOAc. The extract was washed with brine, dried and concentrated to dryness. The residue was purified by chromatography on silica gel (ethyl acetate/hexanes = 0-80percent) to give 1.6 g of ethyl ester intermediate.
  • 2
  • [ 65370-42-5 ]
  • [ 1265355-07-4 ]
  • [ 1265361-32-7 ]
YieldReaction ConditionsOperation in experiment
With caesium carbonate; In N,N-dimethyl-formamide; at 20℃; Step 1: Ethyl 2-(6-(4-chloropyridin-2-yloxy)- 1 -hydroxy-4-methyl- 1 ,3- dihydrobenzo[c] [1,2] oxaborol-3-yl) acetate[0523] To a mixture of ethyl 2-(l ,6-dihydroxy-4-methyl-l ,3- dihydrobenzo[c][l,2]oxaborol-3-yl)acetate (2 g, 8 mmol, 1 eq.) and 4-chloro-2- nitropyridine (2.53 g, 16 mmol, 2 eq.) in 50 ml DMF was added cesium carbonate (7.8 g, 24 mmol, 3 eq.). The reaction was stirred at room temperature overnight. It was then quenched by water, extracted with EtOAc, washed with brine, dried over Na2SO4, and concentrated under reduced pressure. The crude was purified by column chromatography on silica gel (DCM/methanol = 19:1 to 4:1) to give desired product as light yellow oil. MS (ESI) m/z = 721 [2M-H]+.
  • 3
  • [ 65370-42-5 ]
  • [ 1265355-07-4 ]
  • [ 1265356-77-1 ]
 

Historical Records

Categories