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Chemical Structure| 125923-10-6 Chemical Structure| 125923-10-6
Chemical Structure| 125923-10-6

1-(2-Aminoethyl)-1H-pyrrole-2,5-dione

CAS No.: 125923-10-6

4.5 *For Research Use Only !

Cat. No.: A623105 Purity: 98%

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Product Details of [ 125923-10-6 ]

CAS No. :125923-10-6
Formula : C6H8N2O2
M.W : 140.14
SMILES Code : O=C(C=C1)N(CCN)C1=O
MDL No. :MFCD14619234

Safety of [ 125923-10-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

Application In Synthesis of [ 125923-10-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 125923-10-6 ]

[ 125923-10-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 125923-10-6 ]
  • [ 198561-07-8 ]
  • C26H23N3O5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
90% Fmoc-Pra-OH (75.0 mg, 0.22mmol), HOBt (34.2 mg, 0.22 mmol) and DIC (34.1 muL, 0.22 mmol) were dissolved in THF (5 mL) and the solution was stirred for 5 min. Then N-(2-aminoethyl)maleimide trifluoroacetate (55.9 mg, 0.22 mmol) and DIEA (37.6 muL, 0.22 mmol)dissolved in 1 mL of DMF was added and the resulting mixture was stirred for 8 h at rt. 50 mL of EtOAc was added and it was extracted with 0.5 M HCl (3 × 20 mL) and 0.5 M NaOH (3 × 20 mL). The combined organic layer was dried over Na2SO4 and evaporated in vacuo. The crude product was purified by column chromatography (EtOAc/acetone 3:1) to yield 91.0 mg (90percent) of pure 1 as a white solid.
 

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