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Chemical Structure| 1258861-50-5 Chemical Structure| 1258861-50-5

Structure of 1258861-50-5

Chemical Structure| 1258861-50-5

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Product Details of [ 1258861-50-5 ]

CAS No. :1258861-50-5
Formula : C18H22N6
M.W : 322.41
SMILES Code : CN1N=CC=C1C2=NN=C(N3CCC(NC)CC3)C4=C2C=CC=C4

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Application In Synthesis of [ 1258861-50-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1258861-50-5 ]
  • Downstream synthetic route of [ 1258861-50-5 ]

[ 1258861-50-5 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 1258861-50-5 ]
  • [ 189807-21-4 ]
  • [ 1258861-20-9 ]
YieldReaction ConditionsOperation in experiment
86% With triethylamine In dichloromethane at 20℃; for 3 h; EXAMPLE 14-Fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamideTreat a solution of N-methyl-1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-amine (2.8 g, 8.68 mmol) and triethylamine (3.36 mL, 26 1 mmol) in CH2Cl2 (30 mL) with 4-fluoro-2-(trifluoromethyl)benzoyl chloride (2.14 mL, 10.42 mmol). Stir for 3 h at ambient temperature. Concentrate the reaction mixture under reduced pressure. Purify the resulting residue by flash silica gel chromatography (hexane:ethyl acetate:2 M NH3 in MeOH=20:5:1) to provide the free base as a yellow foam (3.83 g, 86percent). ES/MS m/z 513.0 (M+1).
References: [1] Patent: US2010/324048, 2010, A1, . Location in patent: Page/Page column 6.
 

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