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Chemical Structure| 1256815-03-8 Chemical Structure| 1256815-03-8

Structure of 1256815-03-8

Chemical Structure| 1256815-03-8

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Product Details of [ 1256815-03-8 ]

CAS No. :1256815-03-8
Formula : C10H7F3O3
M.W : 232.16
SMILES Code : O=C(O)CC(CC1=CC(F)=C(F)C=C1F)=O

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Application In Synthesis of [ 1256815-03-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1256815-03-8 ]

[ 1256815-03-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1256815-03-8 ]
  • [ 486460-21-3 ]
  • [ 764667-65-4 ]
YieldReaction ConditionsOperation in experiment
91% Dichloromethane (100 ml) and the keto acid compound (10.0 g, 43.07 mmol) prepared in Example 8 were added to a 250 ml three-necked flask, and dissolved by stirring. Oxalyl chloride (6.56 g, 51.68 mmol) was added dropwise at 10 to 15 C, and the dropwise addition was completed, and the mixture was heated to 30 to 35 C to stir the reaction. The reaction was completed, and concentrated under reduced pressure at 30 to 40 C to dryness to pale-yellow liquid (10.91 g, 43.64 mmol), methylene chloride (100 ml), triethylamine (5.79 g, 57.24 mmol) and the above yellow liquid (10.0 g, 52.04 mmol) was dissolved by stirring. The solution of the free base (13.0 g, 52.04 mmol) / dichloromethane (20 ml) of the compound of the formula a was added dropwise to 0 to 5 C, and the dropwise addition was completed. After the completion of the dropwise addition, the mixture was heated to 10 to 15 C to stir the reaction. The reaction was completed, water was added and stirred. Layering, taking the lower organic phase and discarding the upper aqueous phase. The organic phase was washed with a 5% aqueous solution of sodium chloride and concentrated to dryness to dryness to dryness to afford white solid (19.24 g, 47.36 mmol) as a ketoamide compound in a molar yield of 91%.
 

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