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Chemical Structure| 125471-32-1 Chemical Structure| 125471-32-1

Structure of 125471-32-1

Chemical Structure| 125471-32-1

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Product Details of [ 125471-32-1 ]

CAS No. :125471-32-1
Formula : C16H14N4S
M.W : 294.37
SMILES Code : S=C(N/N=C/C1=C(C2=CC=CC=C2)NC3=C1C=CC=C3)N

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Application In Synthesis of [ 125471-32-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 125471-32-1 ]

[ 125471-32-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 25365-71-3 ]
  • [ 79-19-6 ]
  • [ 125471-32-1 ]
YieldReaction ConditionsOperation in experiment
91% With acetic acid; for 1h;Reflux; The mixture of equimolar quantities of 6-phenylimidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde (3) or 2-aryl-1H-indole-3-carbaldehyde (1.0 eq.) and thiosemicarbazide (1.0 eq.) in the acetic acid was heated under reflux for 1h. After the reaction mixture was cooled to the room temperature, formed precipitate was filtered off, washed with acetic acid, water and ethanol and recrystallized.
  • 2
  • [ 125471-32-1 ]
  • [ 13380-67-1 ]
  • N-(4-bromophenyl)-2-{4-oxo-2-[(2-phenyl-1H-indol-3-ylmethylene)hydrazono]thiazolidin-5-yl}acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
71% With sodium acetate; acetic acid;Reflux; General procedure: The mixture of appropriate thiosemicarbazone (1.0 eq.) and appropriate [C2]2+ synthon (1.0 eq.) (maleic anhydride, N-arylmaleimide, β-aroylacryclic acid, α-halogenocarboxylic acids, α-bromo-γ-butyrolactone), sodium acetate (1.0 eq.) in acetic acid was heated under reflux for 2-4h. The reaction proceeding was monitored by TLC. After the reaction, the mixture was cooled to the room temperature; the obtained precipitate was filtered off, washed with acetic acid, water and ethanol and recrystallized. For compounds 1d, 73-75: the mixture of maleic anhydride (1.0 eq) and amino acid (1.0 eq) in acetic acid was heated under reflux for 1h. To the reaction mixture thiosemicarbasone (1.0 eq) was added. The reaction mixture was heated under reflux for 3h. The reaction proceeding was monitored by TLC. After the reaction mixture was cooled to room temperature the obtained precipitate was filtered off and recrystallized.
 

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