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Chemical Structure| 1246299-11-5 Chemical Structure| 1246299-11-5

Structure of 1246299-11-5

Chemical Structure| 1246299-11-5

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Product Details of [ 1246299-11-5 ]

CAS No. :1246299-11-5
Formula : C17H24F2
M.W : 266.37
SMILES Code : CCCCCC1CCC(C2=C(F)C(F)=CC=C2)CC1

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Application In Synthesis of [ 1246299-11-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1246299-11-5 ]

[ 1246299-11-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 56309-94-5 ]
  • [ 1246299-11-5 ]
  • 1-(2,3-difluoro-4-(4-pentylcyclohexyl)phenyl)-4-(1,4-dioxaspiro[4,5]decan-8-yl)cyclohexanol [ No CAS ]
YieldReaction ConditionsOperation in experiment
The compound (43) (30.0 g) and THF (200 ml) were put in a reaction vessel under a nitrogen atmosphere, and cooled to -73 °C. s-Butyllithium (1. 03 M, in a n-hexane and cyclohexane solution; 131.2 ml) was added dropwise thereto in the temperature range of -74 °C to -65 °C, and the mixture was stirred for another 30 minutes. Subsequently, 4-(1,4-dioxospiro[4,5]decan-8-yl) cyclohexanone (2)(32.2 g) in a THF (100 ml) solution was added dropwise thereto in the temperature range of -76 °C to -65 °C, and the stirring was continued for another 20 hours while the mixture was allowed to return to 25 °C. Then, the reaction mixture was poured into a vessel containing ammonium chloride (14.5 g) and ice-water (500 ml), and mixed. Toluene (600 ml) was added thereto and the mixture was allowed to separate into organic and aqueous phases, and then an extractive operation was carried out. The organic phase was fractionated, and washed sequentially with water and a saturated aqueous solution of sodium hydrogencarbonate and brine, and then dried over anhydrous magnesium sulfate. Then the solvent of the solution was distilled off under reduced pressure, and the residue was purified with a fractional operation by means of column chromatography using a mixed solvent of toluene and ethyl acetate (toluene: ethyl acetate= 5:3 by volume) as an eluent and silica gel as a stationary phase powder and dried, giving 69.3 g of 1-(2,3-difluoro-4-(4-pentylcyclohexyl)phenyl-4-(1,4-dioxaspiro[4,5]decan-8-yl)cyclohexanol (44).
 

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