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Chemical Structure| 1242156-74-6 Chemical Structure| 1242156-74-6

Structure of 1242156-74-6

Chemical Structure| 1242156-74-6

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Product Details of [ 1242156-74-6 ]

CAS No. :1242156-74-6
Formula : C9H11BrN2O
M.W : 243.10
SMILES Code : CN1CC(OC2=CN=C(Br)C=C2)C1

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Application In Synthesis of [ 1242156-74-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1242156-74-6 ]

[ 1242156-74-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 910543-72-5 ]
  • [ 1242156-74-6 ]
  • [ 1242156-75-7 ]
YieldReaction ConditionsOperation in experiment
40% To a solution of 2-Bromo-5-(1-methyl-azetidin-3-yloxy)-pyridine (0.327 g, 1.32 mmol) and 3-Amino-5-bromo-1-methyl-1H-pyridin-2-one (0.321 g, 1.58 mmol) in dioxane (5.5 mL) add Cs2CO3 (0.645 g, 1.98 mmol), xantphos (0.153 g, 0.264 mmol) and bubbled argon through reaction mixture for 15 min. Add Pd (OAc)2 (0.03 g, 0.132 mmol) in the end. The reaction was heated at 100 C. under argon for 3 h. TLC shows 2-Bromo-5-(1-methyl-azetidin-3-yloxy)-pyridine was gone. The reaction mixture was treated with water (30 mL) and extracted with dichloromethane (3*20 mL). Organic phase was concentrated and loaded onto silica gel column separation. Using 3-5% MeOH in DCM gave 5-bromo-1-methyl-3-[5-(1-methyl-azetidin-3-yloxy)-pyridin-2-ylamino]-1H-pyridin-2-one as green solid (200 mg, 40% yield).
 

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