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Chemical Structure| 1241914-79-3 Chemical Structure| 1241914-79-3

Structure of 1241914-79-3

Chemical Structure| 1241914-79-3

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Product Details of [ 1241914-79-3 ]

CAS No. :1241914-79-3
Formula : C8H4ClF3O
M.W : 208.57
SMILES Code : O=C(Cl)C(F)(F)C1=CC=C(F)C=C1
MDL No. :MFCD26729260

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Application In Synthesis of [ 1241914-79-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1241914-79-3 ]

[ 1241914-79-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1241914-79-3 ]
  • [ 39549-79-6 ]
  • [ 1241915-31-0 ]
YieldReaction ConditionsOperation in experiment
69% With triethylamine; In 1,2-dichloro-ethane; at 20℃; 00325] Step B: To a solution of 2-(2,2-difluoro-2-(4-fluorophenyl)acetamido)-4- methylbenzamide (5.85 g, 0.0181 mol) in DCE (120 mL) were added TEA (91.5 mL, 0.724 mol) and chlorotrimethylsilane (34.4 mL, 0.272 mol) at rt. The reaction mixuture was stirred at 85 0C overnight. After cooling to rt, the solid was filtered and the filtrate was concentrated to dryness. The residue was taken in a mixture of EtOAc/THF (1: 1) and washed with water and brine. Pure product was obtained after crystallization from hot EtOAc (2.02 g, 37percent); LC-MS (ESI) m/z 305 (M+H)+.
 

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