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Chemical Structure| 1236030-11-7 Chemical Structure| 1236030-11-7

Structure of 1236030-11-7

Chemical Structure| 1236030-11-7

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Product Details of [ 1236030-11-7 ]

CAS No. :1236030-11-7
Formula : C14H19F3N2O3
M.W : 320.31
SMILES Code : O=C(OC(C)(C)C)N[C@@H](CC1=CC=C(C(F)(F)F)N=C1)CO
MDL No. :MFCD23703252

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1236030-11-7 ]

[ 1236030-11-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1236030-11-7 ]
  • [ 405939-39-1 ]
  • [ 944805-59-8 ]
YieldReaction ConditionsOperation in experiment
43% tert-Butyl (5-bromo-l,3-thiazol-2-yl)((2S)-2-((tert- butoxycarbonyl)amino)-3-(6-(trifluoromethyl)-3-pyridinyl)propyl)carbamate: To a 100 mL round-bottomed flask was added <strong>[405939-39-1]tert-butyl 5-bromothiazol-2-ylcarbamate</strong> (1.5 g, 5.4 mmol), CS2CO3 (3.5 g, 11 mmol), and DMF (0.41 mL, 5.4 mmol). The mixture was stirred at 50 0C and treated dropwise via syringe with (S)-3-(tert-butyloxycarbonyl)-4-((6- (trifluoromethyl)pyridin)[l,2,3]-oxathiazolidine-2-oxide (2.4 g, 6.4 mmol) in DMF (1 mL). The mixture was then stirred at 50 0C for 1 hour. The mixture was diluted with ether and washed with brine, dried over Na2SOzI, filtered, and concentrated in vacuo. The product thus obtained was adsorbed onto a plug of silica gel and chromatographed through a Redi-Sep pre-packed silica gel column (40 g), eluting with gradient (5 - 50 % EtOAc in hexane), to provide tert-butyl (5-bromo-l,3-thiazol-2-yl)((2S)-2-((tert- butoxycarbonyl)amino)-3-(6-(trifluoromethyl)-3-pyridinyl)propyl)carbamate (1.35 g, 43 %): LCMS (API-ES) m/z (%): 582.2 (100%, M++H).
 

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