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Chemical Structure| 123486-66-8 Chemical Structure| 123486-66-8

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Chemical Structure| 123486-66-8

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Product Citations

Zhang, Yueteng ; Ji, Peng ; Meng, Xiang ; Gao, Feng ; Zeng, Fanxun ; Wang, Wei

Abstract: A simple arylamine-catalyzed Mannich-cyclization cascade reaction was developed for facile synthesis of substituted 2H-benzo[h]chromenes, e.g., I (R1 = Ph, 2-MeOC6H4, furan-2-yl, 2-bromopyridin-3-yl, etc.; R2 = H, Cl, O2N, AcNH, etc.). The notable feature of the process includes the efficient generation of ortho-quinone methides (o-QMs) catalyzed by o-phenylenediamine. The mild reaction conditions allows for a broad spectrum of 1- and 2-naphthols and trans-cinnamaldehydes R1CH:CHCHO to engage in the cascade sequence with high efficiency.

Keywords: aminocatalysis ; cascade reaction ; chromenes ; organocatalysis ; quinone methide

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Product Details of [ 123486-66-8 ]

CAS No. :123486-66-8
Formula : C10H7F3O
M.W : 200.16
SMILES Code : O=C/C=C/C1=CC=CC=C1C(F)(F)F
MDL No. :N/A

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