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Chemical Structure| 123266-63-7 Chemical Structure| 123266-63-7

Structure of 123266-63-7

Chemical Structure| 123266-63-7

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Product Details of [ 123266-63-7 ]

CAS No. :123266-63-7
Formula : C9H7ClO2
M.W : 182.60
SMILES Code : O=C(Cl)C1=C(OCC2)C2=CC=C1
MDL No. :MFCD06658967

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Application In Synthesis of [ 123266-63-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 123266-63-7 ]

[ 123266-63-7 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 35700-40-4 ]
  • [ 123266-63-7 ]
YieldReaction ConditionsOperation in experiment
With oxalyl dichloride; at 20℃; for 2h; EXAMPLE 39; 2-[f2,3-Dihydro-benzofuran-7-carbonyl)-aminol-indan-2-carboxylic acid ethyl ester (39):To a solution of 2,3-dihydro-benzofuran-7-carboxylic acid (394mg, 2.4mmol) in DCM (1OmL) is added oxalyl chloride (0.85mL, 9.6mmol). The resulting solution is stirred at RT for 2h. After the removal of DCM and excess oxalyl chloride, the residue, 2-amino-indan-2- carboxylic acid ethyl ester (500mg, 2.4mmol) and DIPEA (3.17mL, 19.2mmol) are dissolved in DCM (2OmL). The resulting solution is stirred at RT overnight. The reaction solution is diluted with DCM (4OmL) and washed with water (I x 5mL) and brine (2 x 5mL). The67 <n="69"/>organic layer is dried over anhydrous Na2SO4 and concentrated in vacuo. The residue is purified by flash column chromatography (12Og silica gel, gradient elution: 0%-20% EtOAc in heptane) to give a pure product (39) as white solid (635mg, 75%).1H NMR (CDCl3, 300MHz): delta 1.23(t, 3H), 3.22(t, 2H), 3.40(d, 2H), 3.77(d, 2H), 4.26(q, 2H), 4.67(t, 2H), 6.93(t, IH), 7.17-7.30(m, 6H), 7.87(d, IH), 8.18(s, H) LC/MS (ES+) m/z = 352.12
  • 2
  • [ 123266-63-7 ]
  • [ 22795-99-9 ]
  • [ 108551-43-5 ]
  • 3
  • [ 79-37-8 ]
  • [ 35700-40-4 ]
  • [ 123266-63-7 ]
YieldReaction ConditionsOperation in experiment
In N-methyl-acetamide; dichloromethane; PREPARATION 35 2,3-Dihydrobenzo[b]furan-7-oyl chloride 2,3-Dihydrobenzo[b]furan-7-oic acid (3 g) (see Preparation 32) was suspended in anhydrous dichloromethane (30 ml) and oxalyl chloride (3.5 g) added, followed by addition of dimethylformamide (3 drops). The mixture was stirred at room temperature for 2.5 hours, the solvent then removed under reduced pressure, the resulting residue dissolved in dichloromethane and the solvent removed under reduced pressure. The residue was again dissolved in dichloromethane and the solvent removed under reduced pressure to give 2,3-dihydrobenzo[b]furan-7-oyl chloride as a pink solid (3.3 g).
 

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