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Chemical Structure| 1231749-32-8 Chemical Structure| 1231749-32-8

Structure of 1231749-32-8

Chemical Structure| 1231749-32-8

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Product Details of [ 1231749-32-8 ]

CAS No. :1231749-32-8
Formula : C8H7NO3
M.W : 165.15
SMILES Code : O=C1OC2=CC(O)=CC(C)=C2N1
MDL No. :MFCD24620207

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Application In Synthesis of [ 1231749-32-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1231749-32-8 ]

[ 1231749-32-8 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 1231749-32-8 ]
  • [ 7043-09-6 ]
  • [ 1231748-90-5 ]
  • 2
  • [ 1231749-32-8 ]
  • [ 1074-40-4 ]
  • [ 1231749-92-0 ]
YieldReaction ConditionsOperation in experiment
42% With potassium carbonate; In N,N-dimethyl-formamide; at 20.0℃; for 2.0h; Step 3: 6-(6-chloro-2-methoxypyrimidin-4-yloxy)-4-methylbenzo[d]oxazol-2(3H)-one; 0.19 g (1.01 mmol) <strong>[1074-40-4]4,6-dichloro-2-methoxypyrimidine</strong>, 0.18 g (1.04 mmol) 6-hydroxy-4-methyl-3H-benzoxazol-2-one and 0.15 g (1.09 mmol) potassium carbonate in 1.5 mL DMF were stirred for 2 h at RT. Then water was added and the precipitate formed was suction filtered, washed and dried.Yield: 145 mg (42percent of theory)ESI-MS: m/z=308/310 (Cl) (M+H)+ Rt(HPLC): 1.41 min (method B)
  • 3
  • [ 1231749-32-8 ]
  • [ 7043-09-6 ]
  • [ 1231749-96-4 ]
YieldReaction ConditionsOperation in experiment
24% With caesium carbonate; In N,N-dimethyl-formamide; at 20℃; for 0.25h; Step 3: 6-(6-chloro-2-cyclopropylpyrimidin-4-yloxy)-4-methylbenzo[d]oxazol-2(3H)-one; 0.10 g (0.53 mmol) <strong>[7043-09-6]4,6-dichloro-2-cyclopropylpyrimidine</strong> were added to 95 mg (0.55 mmol) 6-hydroxy-4-methylbenzo[d]oxazol-2(3H)-one and 0.21 g (0.63 mmol) caesium carbonate in 1.5 mL DMF after 15 min and the mixture was stirred overnight at RT. The reaction mixture was purified by preparative HPLC-MS. The fractions containing product were combined and freeze-dried.Yield: 43 mg (24% of theory)ESI-MS: m/z=318/320 (Cl) (M+H)+ Rt(HPLC): 1.47 min (method B)
 

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