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Chemical Structure| 1227177-83-4 Chemical Structure| 1227177-83-4

Structure of 1227177-83-4

Chemical Structure| 1227177-83-4

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Product Details of [ 1227177-83-4 ]

CAS No. :1227177-83-4
Formula : C8H10F3NO4S
M.W : 273.23
SMILES Code : O=S(C(F)(F)F)(OC1=CCN(C(C)=O)CC1)=O

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Application In Synthesis of [ 1227177-83-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1227177-83-4 ]

[ 1227177-83-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1227177-83-4 ]
  • [ 73183-34-3 ]
  • [ 1227068-67-8 ]
YieldReaction ConditionsOperation in experiment
With potassium acetate;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; In 1,4-dioxane; at 80℃; for 16.0h;Inert atmosphere; STEP 2. 1-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-5,6-DIHYDROPYRIDIN-1(2H)-YL)ETHANONE 1-acetyl-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate (6.77 g, 24.8 mmol), bis(pinacolato)diboron (6.92 g, 27.3 mmol), potassium acetate (2.93 g, 49.6 mmol), and 1,1'-bis(diphenylphosphino)ferrocene]dichloride palladium(ii)complex with dichloramethane (1.01 g, 1.24 mmol) were taken up in dioxane (83 mL). The mixture was purged with nitrogen and then was heated to 80 C. After 16 h, the reaction mixture was cooled to RT, diluted with 150 mL of EtOAc and washed with 50 mL of water and 50 mL of brine, then dried over MgSO4. Filtration and concentration under reduced pressure, followed by flash chromatography on silica gel (0% to 90% EtOAc/hexanes) afforded 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridin-1(2H)-yl)ethanone as an orange oil. MS (ESI, pos. ion) m/z: 252.1 (M+1).
 

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