Home Cart Sign in  
Chemical Structure| 122607-15-2 Chemical Structure| 122607-15-2

Structure of 122607-15-2

Chemical Structure| 122607-15-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 122607-15-2 ]

CAS No. :122607-15-2
Formula : C12H11NO4
M.W : 233.22
SMILES Code : O=C(C(C1=O)=CC2=C(O1)C=C(N(C)C)C=C2)O
MDL No. :MFCD21604258

Safety of [ 122607-15-2 ]

Application In Synthesis of [ 122607-15-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 122607-15-2 ]

[ 122607-15-2 ] Synthesis Path-Downstream   1~3

  • 2
  • [ 2033-24-1 ]
  • [ 41602-56-6 ]
  • [ 122607-15-2 ]
YieldReaction ConditionsOperation in experiment
With piperidine; acetic acid; In ethanol; for 3h;Reflux; General procedure: We performed the Vilsmeier-Haack reaction to add the aldehyde function to the 2-aminophenol derivative. The phosphoryl oxychloride POCl3 (1.2 equiv in 3.0 equiv of anhydrous DMF) was carefully added dropwise to the previous synthesis product (also in anhydrous DMF: 200 mul for 1 mmol) under argon at 0 C. The reaction mixture was stirred 15 min at 0 C, then 15 min at room temperature,15 min at 37 C and finally 30 min at 80-90 C. After cooling, addition of ice and Na2CO3 in the reaction mixture and stirring, we obtain a precipitate (not pure but the cyclisation selects the desired coumarinic end product). This reaction step was used for the compounds 18-22. The previously synthesized salicylaldehyde (1.0 equiv) was dissolved in EtOH (10 ml for 1 mmol). Meldrum acid (1.2 equiv) was added to the stirred solution. Piperidineand acetic acid were added dropwise to catalyse the reaction (six drops for 1 mmol). The solution was stirred and heated 3 h under reflux. After cooling, the yellow to orange precipitate was filtered and obtained pure. This final reaction step was used for all the compounds (the only synthesis step of 17 and 23). 5.1.5.5 7-(Dimethylamino)-2-oxo-2H-chromene-3-carboxylic acid (21) 1H NMR (DMSO-d6) delta ppm 8.60 (s, 1H), 7.66 (d, J = 9, 1H), 6.81 (d, J = 9, 1H), 6.58 (s, 1H), 3.09 (s, 6H). 13C NMR (DMSO-d6) delta ppm 164.97 (C), 157.94 (C), 155.41 (C), 149.99 (CH), 149.96 (C), 131.98 (CH), 131.92 (C), 110.71 (C), 108.40 (CH), 108.06 (CH), 96.91 (C), 40.53 (CH3) MS (APCI): m/z = 233.93 (MH+) HRMS: m/z calcd for [C12H12NO4] 234.0766, measured 234.0777.
  • 3
  • [ 1035373-85-3 ]
  • [ 122607-15-2 ]
  • N-(2-(2-((6-chlorohexyl)oxy)ethoxy)ethyl)-7-(dimethylamino)-2-oxo-2H-chromene-3-carboxamide [ No CAS ]
 

Historical Records

Technical Information

Categories