Home Cart Sign in  
Chemical Structure| 1225278-65-8 Chemical Structure| 1225278-65-8

Structure of 1225278-65-8

Chemical Structure| 1225278-65-8

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1225278-65-8 ]

CAS No. :1225278-65-8
Formula : C11H7ClF2N2O
M.W : 256.64
SMILES Code : NC1=CC(F)=C(OC2=CC(Cl)=NC=C2)C=C1F
MDL No. :MFCD26961015

Safety of [ 1225278-65-8 ]

Application In Synthesis of [ 1225278-65-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1225278-65-8 ]

[ 1225278-65-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1052114-81-4 ]
  • [ 1225278-65-8 ]
  • N-(2,5-difluoro-4-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)phenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide [ No CAS ]
  • 2
  • [ 1052114-81-4 ]
  • [ 1225278-65-8 ]
  • N-(4-((2-chloropyridin-4-yl)oxy)-2,5-difluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
54% With 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20℃; Example 10: A mixture of Example A8 (0.363 g, 1.559 mmol), Example Al (0.200 g, 0.779 mmol), and TBTU (0.751 g, 2.338 mmol) in DMF (15 mL) was treated with Et3N (0.652 mL, 4.68 mmol) and stirred at RT overnight. The mixture was treated with brine, extracted with EtOAc (2x) and the combined organics were washed successively with 5% citric acid (2x), satd. NaHCO3 (ix), 5% LiC1 (ix), and brine (ix), dried over Mg504, concentrated to dryness and purified via silica gel chromatography (EtOAc/Hex). The resulting material was treated with 4:1 MeCN/H20, the solid collected via filtration and driedafford N-(4-((2-chloropyridin-4-yl)oxy)-2,5-difluorophenyl)-5 -(4-fluorophenyl)-4-oxo- 1,4- dihydropyridine-3-carboxamide (200 mg, 54%) as a white solid. ?H NMR (400 MHz, DMSO-d6): oe 13.48 (s, 1 H), 12.72 (s, 1 H), 8.60-8.58 (m, 2 H), 8.30 (d, J = 5.3 Hz, 1 H), 8.09 (s, 1 H), 7.67-7.65 (m, 3 H), 7.26-7.23 (m, 2 H), 7.17 (s, 1 H), 7.06 (s, 1 H); MS (ESI) mlz: 472.0 (M+Hj.
 

Historical Records