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Chemical Structure| 1222073-98-4 Chemical Structure| 1222073-98-4

Structure of 1222073-98-4

Chemical Structure| 1222073-98-4

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Product Details of [ 1222073-98-4 ]

CAS No. :1222073-98-4
Formula : C12H17NO3
M.W : 223.27
SMILES Code : O=C(OC1=CC=CC(C(O)C)=C1)N(CC)C
MDL No. :MFCD30730049
InChI Key :UPFRTBVKMHUBLD-UHFFFAOYSA-N
Pubchem ID :46217697

Safety of [ 1222073-98-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1222073-98-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1222073-98-4 ]

[ 1222073-98-4 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 123441-03-2 ]
  • [ 855300-09-3 ]
  • [ 1222073-98-4 ]
  • 2
  • [ 1222073-98-4 ]
  • (R)-3-(1-(dimethylamino)ethyl) phenylethyl(methyl)carbamate [ No CAS ]
  • [ 123441-03-2 ]
  • 3
  • [ 1222073-98-4 ]
  • [ 127-19-5 ]
  • [ 123441-03-2 ]
YieldReaction ConditionsOperation in experiment
To a 100 ml RB flask, MDC (23 ml), ethyl-methyl-carbamic acid 3-(1-hydroxy-ethyl)-phenyl ester (2.24 g) and triethylamine (2.78 ml) were added and cooled the reaction mass -10 to 0 C. To the above reaction mixture, added methane sulfonyl chloride (1.1 ml) drop wise and stirred for 10 min. Purged DMA gas through the reaction mixture at 25-30 C. for 30 min followed by adjusted the pH 1 to 2 by conc. HCl. Layers were separated, organic layer was extracted with DM water. Combined the aqueous layers, basify with 1:1 NaOH and extracted with ethyl acetate. Ethyl acetate was dried over anhydrous Na2SO4 and distilled out ethyl acetate to obtained 2.15 g of Rivastigmine base (Yield: 97%, HPLC: 96.94%, Chiral HPLC: 89.76%).
 

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