Structure of 1217501-27-3
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
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CAS No. : | 1217501-27-3 |
Formula : | C9H15BN2O4 |
M.W : | 226.04 |
SMILES Code : | CC1=NN(C(OC(C)(C)C)=O)C(B(O)O)=C1 |
MDL No. : | MFCD15143457 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Num. heavy atoms | 16 |
Num. arom. heavy atoms | 5 |
Fraction Csp3 | 0.56 |
Num. rotatable bonds | 4 |
Num. H-bond acceptors | 5.0 |
Num. H-bond donors | 2.0 |
Molar Refractivity | 59.22 |
TPSA ? Topological Polar Surface Area: Calculated from |
84.58 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
0.0 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
0.84 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
-0.35 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
-0.25 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
-1.62 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
-0.28 |
Log S (ESOL):? ESOL: Topological method implemented from |
-1.74 |
Solubility | 4.13 mg/ml ; 0.0183 mol/l |
Class? Solubility class: Log S scale |
Very soluble |
Log S (Ali)? Ali: Topological method implemented from |
-2.2 |
Solubility | 1.43 mg/ml ; 0.00632 mol/l |
Class? Solubility class: Log S scale |
Soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-0.6 |
Solubility | 57.3 mg/ml ; 0.254 mol/l |
Class? Solubility class: Log S scale |
Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
No |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
No |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-7.08 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
0.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
1.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
2.91 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; In 1,4-dioxane; water; at 110℃; for 1h;microwave irradiation; Inert atmosphere; | A mixture of {1 -[4-(6-bromo-3-phenyl-imidazo[1 ,2-a]pyridin-2-yl)-phenyl]- cyclobutyl}-carbamic acid tert-butyl ester (50 mg) and 1 -tert-butoxycarbonyl-3- methylpyrazole-5-boronic acid (44 mg) in dioxane (1 mL) and water (0.43 mL) was placed under argon and [1 ,1 -bis-(diphenylphosphino)-ferrocene]- dichloropalladium-dichlormethane-complex (7.9 mg) added. The mixture was heated at 1 10 C under microwave irradiation for 60 minutes. On cooling the mixture was partitioned between DCM and water and extracted. The organic portion was dried and concentrated in vacuo to give the crude title compound which was used in the next step without further purification |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate; In 1,2-dimethoxyethane; water; at 130 - 150℃; for 4.5h;Microwave irradiation; | Pd(PPh3)4 (190.0 mg, 0.17 mmol) was added to suspension of 5-bromo-3-iodopyridin-2-amine (500.0 mg, 1.67 mmol), <strong>[1217501-27-3](1-(tert-butoxycarbonyl)-3-methyl-1H-pyrazol-5-yl)boronic acid</strong> (755.0 mg, 3.34 mmol), Cs2CO3 (1600.0 mg, 5.01 mmol), H2O (3.0 mL) and DME (12.0 mL). The reaction mixture was allowed to react in microwave under conditions of 100 W and 130 C. for 2 hours and 30 minutes, followed by 100 W and 150 C. for 2 hours and then cooled to room temperature. Water was added to the reaction mixture, and it was extracted 2 times with EtOAc. The organic layer was dried over anhydrous Na2SO4, filtered and then concentrated under reduced pressure. The residue was purified by column chromatography (MeOH:DCM=1:40) on silica. The fractions containing the product were collected and evaporated to obtain brown solid compound which is the mixture of 5-bromo-3-(3-methyl-1H-pyrazol-5-yl)pyridin-2-amine and 9-bromo-2-methylpyrazolo[1,5-c]pyrido[3,2-e]pyrimidin-5-ol (78.0 mg). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
73% | With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate; In 1,2-dimethoxyethane; at 100℃; | a. Preparation of (6-(3-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-8-yl)methanol (14) Compound 5 (450 mg, 1.97 mmol, 1.0 eq), <strong>[1217501-27-3](2-tert-butoxycarbonyl-5-methyl-pyrazol-3-yl)boronic acid</strong> (937 mg, 4.14 mmol, 2.1 eq), Pd(dppf)Cl2.CH2Cl2 (144 mg, 0.197 mmol, 0.10 eq), 1 M sodium carbonate solution (1.97 mL, 1.97 mmol, 1 eq) and DME (10 mL) were added to a large microwave vial. The vial was capped and stirred overnight at 100 C. The reaction was washed with water and brine and extracted with EtOAc (2*). The organics were combined, dried (MgSO4), and concentrated to dryness. Purification by flash chromatography on silica gel afforded 330 mg (73%) of the title compound: 1H NMR (400 MHz, DMSO-d6) delta 9.15 (s, 1H), 8.45 (s, 1H), 8.16 (s, 1H), 6.63 (s, 1H), 5.62 (s, 1H), 4.88 (d, J=3.3 Hz, 2H), 2.28 (s, 3H); ES-MS [M+1]+: 230.2. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
9 mg | A mixture of 3-bromo-l-(6-methoxy-5-methylpyridin-3-yl)-4,5,7,8-tetrahydro-lH-oxepino[4,5- c]pyrazole (22 mg, 0.052 mmol) and (l-(te/-butoxycarbonyl)-3-methyl-lH-pyrazol-5-yl)boronic acid (25 mg, O.lllmmol) in 1,4-dioxane (0.5 mL) and water (0.215 mL) was treated with PdCl2(dtbpf) (3 mg, 4.60 muiotatauiotaomicronIota) and heated at 80 C using a microwave for 60 min. The reaction mixture was treated with a solution of (l-(tert-butoxycarbonyl)-3-methyl-lW-pyrazol-5-yl)boronic acid (25 mg, 0.111 mmol) in 1,4-dioxane (0.05 mL) and a solution of potassium phosphate (21 mg, 0.099 mmol) in in water (0.02 mL). The reaction mixture was heated at 80 C using a microwave for 120 min. Separately a mixture of 3-bromo-l-(6-methoxy-5-methylpyridin-3-yl)-4,5,7,8-tetrahydro-lW- oxepino[4,5-c]pyrazole (22 mg, 0.052 mmol) and (l-(iert-butoxycarbonyl)-3-methyl-lW-pyrazol-5- yl)boronic acid (25 mg, O.lllmmol) in 1,4-dioxane (0.550 mL) and water (0.215 mL) was treated with [l,3-bis(2,6-diisopropylphenyl)imidazole-2-ylidene)(3-chloropyridyl)dichloropalladium (3.5 mg, 5.20 muiotaetaomicronIota). The mixture was heated at 80 C using a microwave for 60 min. The reaction mixture was treated with a solution of potassium phosphate (21 mg, 0.099 mmol) in water (0.02 mL) and heated at 80 C using a microwave 120 min. Separately a mixture of 3-bromo-l-(6-methoxy-5-methylpyridin-3-yl)-4,5,7,8-tetrahydro-lW- oxepino[4,5-c]pyrazole (22 mg, 0.052 mmol) and (l-(tert-butoxycarbonyl)-3-methyl-lW-pyrazol-5- yl)boronic acid (25 mg, O.lllmmol) in 1,4-dioxane (0.5 mL) and water (0.215 mL) was treated with XPhos Pd G2 (4.09 mg, 5.20 Mmol). The mixture was heated at 80 C using a microwave 60 min. The reaction mixture was treated with a solution of (l-(tert-butoxycarbonyl)-3-methyl-lH-pyrazol-5- yl)boronic acid (25 mg, 0.111 mmol) dissolved in 1,4-dioxane (0.05 mL) and a solution of potassium phosphate (21 mg, 0.099 mmol) in water (0.02 mL) and heated at 80 C using a microwave for 120 min. The three reaction mixtures were combined and partitioned with DCM (10 mL) and water (10 mL). The organic layer was isolated and the aqueous layer was extracted with further DCM (3 x 10 mL). The combined organic layers were passed through a hydrophobic frit and concentrated under reduced pressure to give the crude product (123 mg). The crude product was purified using MDAP (Method A) to give the title compound (9 mg). LCMS (Method C): Rt = 0.96 min, MH+ 340. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In water; N,N-dimethyl-formamide; at 100℃; for 2h;Inert atmosphere; | General procedure: Add N- (2,5-difluorobenzyl) -3-iodopyrazolo [1,5-a] pyrimidin-5-amine (0.52 mmol), 1-Boc-pyrazole-4-boronic acid pinacol Ester (0.78 mmol), anhydrous potassium carbonate (2.08 mmol), tetrakis (triphenylphosphine) palladium (0.052 mmol) were added to a 100 ml reaction tube, replaced with argon 3 times, and 10 ml of anhydrous DMF and 2 ml of water were added.The reaction was performed at 100 C for 2 h under an argon atmosphere, and monitored by TLC (petroleum ether: acetone = 2: 1).After the reaction was completed, it was cooled to 50 C, filtered through celite, and the filtrate was added with water and extracted with ethyl acetate.The organic phase was washed twice with saturated brine, dried over anhydrous sodium sulfate, and concentrated to obtain a crude oily black product. The crude product was purified by column chromatography (TLC, petroleum ether: acetone = 2: 1) to obtain a pale yellow solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In water; N,N-dimethyl-formamide; at 100℃; for 2h;Inert atmosphere; | General procedure: Add N- (2,5-difluorobenzyl) -3-iodopyrazolo [1,5-a] pyrimidin-5-amine (0.52 mmol), 1-Boc-pyrazole-4-boronic acid pinacol Ester (0.78 mmol), anhydrous potassium carbonate (2.08 mmol), tetrakis (triphenylphosphine) palladium (0.052 mmol) were added to a 100 ml reaction tube, replaced with argon 3 times, and 10 ml of anhydrous DMF and 2 ml of water were added.The reaction was performed at 100 C for 2 h under an argon atmosphere, and monitored by TLC (petroleum ether: acetone = 2: 1).After the reaction was completed, it was cooled to 50 C, filtered through celite, and the filtrate was added with water and extracted with ethyl acetate.The organic phase was washed twice with saturated brine, dried over anhydrous sodium sulfate, and concentrated to obtain a crude oily black product. The crude product was purified by column chromatography (TLC, petroleum ether: acetone = 2: 1) to obtain a pale yellow solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In water; N,N-dimethyl-formamide; at 100℃; for 2h;Inert atmosphere; | General procedure: Add N- (2,5-difluorobenzyl) -3-iodopyrazolo [1,5-a] pyrimidin-5-amine (0.52 mmol), 1-Boc-pyrazole-4-boronic acid pinacol Ester (0.78 mmol), anhydrous potassium carbonate (2.08 mmol), tetrakis (triphenylphosphine) palladium (0.052 mmol) were added to a 100 ml reaction tube, replaced with argon 3 times, and 10 ml of anhydrous DMF and 2 ml of water were added.The reaction was performed at 100 C for 2 h under an argon atmosphere, and monitored by TLC (petroleum ether: acetone = 2: 1).After the reaction was completed, it was cooled to 50 C, filtered through celite, and the filtrate was added with water and extracted with ethyl acetate.The organic phase was washed twice with saturated brine, dried over anhydrous sodium sulfate, and concentrated to obtain a crude oily black product. The crude product was purified by column chromatography (TLC, petroleum ether: acetone = 2: 1) to obtain a pale yellow solid. |
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