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Chemical Structure| 1215206-37-3 Chemical Structure| 1215206-37-3

Structure of 1215206-37-3

Chemical Structure| 1215206-37-3

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Product Details of [ 1215206-37-3 ]

CAS No. :1215206-37-3
Formula : C8H7F3N2O3
M.W : 236.15
SMILES Code : FC(F)(F)OC1=CC=C(C([N+]([O-])=O)=C1)NC
MDL No. :MFCD15143571

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Application In Synthesis of [ 1215206-37-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1215206-37-3 ]

[ 1215206-37-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 2267-23-4 ]
  • [ 74-88-4 ]
  • [ 1215206-37-3 ]
YieldReaction ConditionsOperation in experiment
Reference Production Example 206; To a mixture of 2.22 g of 2-nitro-4- trifluoromethoxyaniline and 20 ml of DMF was added 0.44 g of sodium hydride (60% oily), and the mixture was stirred for 10 minutes under ice cool. To this mixture was added 1.42 g of methyl iodide, then, the mixture was stirred for 1 hour at room temperature. Into the reaction mixture, a saturated ammonium chloride aqueous solution was poured, and the mixture was extracted three times with ethyl acetate. The organic layer was dried over magnesium sulfate, then, concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 1.80 g of N-methyl-2- nitro-4-trifluoromethoxyaniline.1H-NMR (CDCl3) delta: 8.10-8.01 (m, 2H), 7.3 7 (dtd, J=9.3, 1.8, 1.0Hz, IH), 6.87 (d, J=9.3Hz, IH), 3.05 (d, J=5.1Hz, 3H)
  • 2
  • [ 1215206-37-3 ]
  • [ 1254166-41-0 ]
YieldReaction ConditionsOperation in experiment
92% With palladium 10% on activated carbon; hydrogen; In methanol; ethanol; at 20℃; under 3102.97 Torr; for 6h;Inert atmosphere; General procedure: Step-e: Synthesis of ethyl 3-amino-4-(methylamino)benzoate (1e) To a solution of ethyl 4-(methylamino)-3-nitrobenzoate (13.0 g, 58 mmol) in methanol (180 mL) was added slurry of 10% Pd/C (1.3 g in 10 mL of ethanol) under nitrogen atmosphere. The flask was kept in a Parr shaker at RT under hydrogen pressure (60 psi) for 5 h. The reaction mixture was filtered through celite bed and concentrated under vacuum to afford the title compound (10.0 g, 88%); 1H NMR (400 MHz, DMSO-d6): δ 7.23 (dd, J=1.6 Hz, J=8.4 Hz 1H), 7.16 (d, J=1.6 Hz, 1H), 6.39 (d, J=8.4 Hz, 1H), 5.38-5.37 (m, 1H), 4.66 (s, 2H), 4.18 (q, J=7.2 Hz, 2H), 2.77 (d, J=5.2 Hz, 3H), 1.26 (t, J=7.2 Hz, 3H); LC-MS: m/z 195.1 (M-1)+.
 

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