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Chemical Structure| 1214350-42-1 Chemical Structure| 1214350-42-1

Structure of 1214350-42-1

Chemical Structure| 1214350-42-1

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Product Details of [ 1214350-42-1 ]

CAS No. :1214350-42-1
Formula : C8H5BrClF3
M.W : 273.48
SMILES Code : FC(C1=CC(Br)=CC=C1CCl)(F)F

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Application In Synthesis of [ 1214350-42-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1214350-42-1 ]

[ 1214350-42-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 773837-37-9 ]
  • [ 1214350-42-1 ]
  • [ 877131-92-5 ]
YieldReaction ConditionsOperation in experiment
92% In water; acetonitrile; at 80.0℃;Inert atmosphere; A solution of 4-bromo-1-(chloromethyl)-2-(trifluoromethyl)benzene (2.707 g, 9.81 mmol) in MeCN (32 mL) and water (4 mL) is treated with sodium cyanide (0.651 g, 12.80 mmol) and the mixture is heated to 80C, under nitrogen, overnight. The RM is allowed to cool to RT and is diluted with water. Acetonitrile is removedunder reduced pressure and the mixture is extracted twice with DCM. The combined organic layers are dried over anh. MgSO4, filtered and concentrated under reduced pressure. Purification by FC (from heptane to heptane/EtOAc = 7/3) affords 2-(4-bromo-2-(trifluoromethyl)phenyl)acetonitrile as a light yellow solid (2.385 g, 92%). LC-MS B: tR = 0.95 mm; no ionization.
 

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