Home Cart Sign in  
Chemical Structure| 1214328-42-3 Chemical Structure| 1214328-42-3

Structure of 1214328-42-3

Chemical Structure| 1214328-42-3

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1214328-42-3 ]

CAS No. :1214328-42-3
Formula : C6H3BrClNO2
M.W : 236.45
SMILES Code : O=C(O)C1=NC(Br)=C(Cl)C=C1
MDL No. :MFCD13185790

Safety of [ 1214328-42-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1214328-42-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1214328-42-3 ]

[ 1214328-42-3 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 86873-60-1 ]
  • [ 1214328-42-3 ]
  • 2
  • [ 1214328-42-3 ]
  • [ 63503-60-6 ]
  • [ 1415898-81-5 ]
YieldReaction ConditionsOperation in experiment
32% With caesium carbonate;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; In N,N-dimethyl-formamide; at 80.0℃;Inert atmosphere; Under nitrogen atmosphere, <strong>[1214328-42-3]6-bromo-5-chloro-pyridine-2-carboxylic acid</strong> (0.38 g, 1.6 mmol), 3-chlorophenylboronic acid (CAN 63503-60-6, 0.33 g, 2.1 mmol), 1,1'-bis(diphenylphosphino)-ferrocene-palladium(II) dichloride methylene chloride complex (CAN 95464-05-4, 30 mg) and cesium carbonate (CAN 534-17-8, 1.6 g, 4.8 mmol) was added into DMF (30 mL). The mixture was stirred at 80 C. overnight. After evaporation of solvents, the crude product was purified by column chromatography (silica gel, 12 g, petroleum ether/ethyl acetate 4/1 firstly, then methanol/methylene chloride 1/10) to give the title compound (0.14 g, 32%) as brown solid; MS (EI): m/e=268.0 [M+H]+.
32% With caesium carbonate;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; In N,N-dimethyl-formamide; at 80.0℃;Inert atmosphere; Under nitrogen atmosphere, <strong>[1214328-42-3]6-bromo-5-chloro-pyridine-2-carboxylic acid</strong> (0.38 g, 1.6 mmol), 3-chlorophenylboronic acid (CAN 63503-60-6, 0.33 g, 2.1 mmol), Iota,Gamma- bis(diphenylphosphino)-ferrocene-palladium(II) dichloride methylene chloride complex (CAN 95464-05-4, 30 mg) and cesium carbonate (CAN 534-17-8, 1.6 g, 4.8 mmol) was added into DMF (30 mL). The mixture was stirred at 80C overnight. After evaporation of solvents, the crude product was purified by column chromatography (silica gel, 12 g, petroleum ether/ethyl acetate 4/1 firstly, then methanol/ methylene chloride 1/10) to give the title compound (0.14 g, 32%) as brown solid; MS (EI): m/e = 268.0 [M+H]+.
  • 3
  • [ 1415898-80-4 ]
  • [ 1214328-42-3 ]
YieldReaction ConditionsOperation in experiment
23% With phosphorus(V) oxybromide; at 80.0℃; for 2.0h; 5-Chloro-1-oxy-pyridine-2-carboxylic acid (3.5 g, 20 mmol) was added into phosphorus oxide tribromide (CAN 7789-59-5, 30 g) at 80 C., stirred for 2 h. The mixture was poured into water (100 mL), extracted with ethyl acetate (3×50 mL), dried over anhydrous sodium sulfate, and solvent removed in vacuo. The crude product was purified by column chromatography (silica gel, 100 g, eluting with 50% ethyl acetate in petroleum ether) to give the title compound (1.12 g, 23%) as grey solid; MS (EI): m/e 236.0 [M+H]+.
23% With phosphorus(V) oxybromide; at 80.0℃; for 2.0h; 5-Chloro-l-oxy-pyridine-2-carboxylic acid (3.5 g, 20mmol) was added into phosphorus oxide tribromide (CAN 7789-59-5, 30 g) at 80C, stirred for 2 h. The mixture was poured into water (100 mL), extracted with ethyl acetate (3 x 50 mL), dried over anhydrous sodium sulfate, and solvent removed in vacuo. The crude product was purified by column chromatography (silica gel, 100 g, eluting with 50% ethyl acetate in petroleum ether) to give the title compound (1.12 g, 23%) as grey solid; MS (EI): m/e 236.0 [M+H]+.
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 1214328-42-3 ]

Bromides

Chemical Structure| 1227561-90-1

A416733 [1227561-90-1]

6-Bromo-5-chloropicolinaldehyde

Similarity: 0.85

Chemical Structure| 1060811-25-7

A299394 [1060811-25-7]

6-Bromo-4-chloropicolinic acid

Similarity: 0.84

Chemical Structure| 21190-87-4

A106467 [21190-87-4]

6-Bromo-2-pyridinecarboxylic acid

Similarity: 0.82

Chemical Structure| 1211516-25-4

A213235 [1211516-25-4]

6-Bromo-5-methylpicolinic acid

Similarity: 0.78

Chemical Structure| 1189513-50-5

A348335 [1189513-50-5]

3-Bromo-5-chloropicolinic acid

Similarity: 0.77

Chlorides

Chemical Structure| 1227561-90-1

A416733 [1227561-90-1]

6-Bromo-5-chloropicolinaldehyde

Similarity: 0.85

Chemical Structure| 1060811-25-7

A299394 [1060811-25-7]

6-Bromo-4-chloropicolinic acid

Similarity: 0.84

Chemical Structure| 1189513-50-5

A348335 [1189513-50-5]

3-Bromo-5-chloropicolinic acid

Similarity: 0.77

Chemical Structure| 886365-46-4

A225570 [886365-46-4]

5-Chloro-3-methylpyridine-2-carboxylic acid

Similarity: 0.76

Chemical Structure| 132308-19-1

A231690 [132308-19-1]

Methyl 5-chloropyridine-2-carboxylate

Similarity: 0.76

Carboxylic Acids

Chemical Structure| 1060811-25-7

A299394 [1060811-25-7]

6-Bromo-4-chloropicolinic acid

Similarity: 0.84

Chemical Structure| 21190-87-4

A106467 [21190-87-4]

6-Bromo-2-pyridinecarboxylic acid

Similarity: 0.82

Chemical Structure| 1211516-25-4

A213235 [1211516-25-4]

6-Bromo-5-methylpicolinic acid

Similarity: 0.78

Chemical Structure| 1189513-50-5

A348335 [1189513-50-5]

3-Bromo-5-chloropicolinic acid

Similarity: 0.77

Chemical Structure| 886365-46-4

A225570 [886365-46-4]

5-Chloro-3-methylpyridine-2-carboxylic acid

Similarity: 0.76

Related Parent Nucleus of
[ 1214328-42-3 ]

Pyridines

Chemical Structure| 1227561-90-1

A416733 [1227561-90-1]

6-Bromo-5-chloropicolinaldehyde

Similarity: 0.85

Chemical Structure| 1060811-25-7

A299394 [1060811-25-7]

6-Bromo-4-chloropicolinic acid

Similarity: 0.84

Chemical Structure| 21190-87-4

A106467 [21190-87-4]

6-Bromo-2-pyridinecarboxylic acid

Similarity: 0.82

Chemical Structure| 1211516-25-4

A213235 [1211516-25-4]

6-Bromo-5-methylpicolinic acid

Similarity: 0.78

Chemical Structure| 1189513-50-5

A348335 [1189513-50-5]

3-Bromo-5-chloropicolinic acid

Similarity: 0.77