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Chemical Structure| 1211531-07-5 Chemical Structure| 1211531-07-5

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Chemical Structure| 1211531-07-5

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Product Details of [ 1211531-07-5 ]

CAS No. :1211531-07-5
Formula : C13H23NO2
M.W : 225.33
SMILES Code : O=C(OC(C)(C)C)N(CCC=C)CCC=C
MDL No. :MFCD22420767

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1211531-07-5 ]
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[ 1211531-07-5 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 1211531-07-5 ]
  • [ 317336-73-5 ]
YieldReaction ConditionsOperation in experiment
90% With Grubbs catalyst first generation In dichloromethane at 45℃; for 2 h; A 1 L round-bottomed flask equipped with a reflux condenser was charged with 500 mL of dichloromethane (DCM), followed by addition of tert-butyl di(but-3-en-1- yl)carbamate (1.00 g, 4.44 mmol), prepared according to the method of Kuhn, K. M. et al., Organic Letters 2010 12 (5), 984-987. The solution was heated up to 45°C. Grubbs 1 generation catalyst (238 mg, 0289 mmol) was added. The reaction mixture was allowed to reflux at 45°C for 2 hours. The solvent was removed with a rotary evaporator. Purification by column chromatography with 4percent ethyl acetate in hexanes yielded 790 mg (4.01 mmol, 9Qpercent) of the title compound as an oil.
References: [1] Organic Letters, 2010, vol. 12, # 5, p. 984 - 987.
[2] Patent: WO2016/164565, 2016, A1, . Location in patent: Page/Page column 9.
[3] Journal of Medicinal Chemistry, 2019, .
 

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