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Chemical Structure| 1211527-74-0 Chemical Structure| 1211527-74-0

Structure of 1211527-74-0

Chemical Structure| 1211527-74-0

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Product Details of [ 1211527-74-0 ]

CAS No. :1211527-74-0
Formula : C5H3ClN4S
M.W : 186.62
SMILES Code : ClC1=C2N=CSC2=NC(N)=N1
MDL No. :MFCD16659148

Safety of [ 1211527-74-0 ]

Application In Synthesis of [ 1211527-74-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1211527-74-0 ]

[ 1211527-74-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 475272-54-9 ]
  • [ 1211527-74-0 ]
  • C17H26N6O2S [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 110℃; for 6h; Intermediate 4 (2.2 mmol) and tert-butyl (35)-3-isopropylpiperazine-l-carboxylate (0.5 g, 2.2 mmol) in DMF (10 mL) and DIPEA (0.34 g, 2.63 mmol) were heated at 110C for 6 h. The reaction mixture was allowed to cool, then stirred overnight at room temperature. The reaction mixture was concentrated in vacuo, then partitioned between EtOAc and water. The organic layers were dried over sodium sulfate and concentrated in vacuo, then the crude material was purified by column chromatography (silica gel: 100- 200 mesh, isohexanes:EtOAc, gradient 50% to 100% EtOAc) to give an off- white foam. This was taken up in 4N HC1 in 1 ,4-dioxane (5 mL) and methanol (1 mL), and stirred for 1 h. The reaction mixture was concentrated in vacuo and triturated with diethyl ether to give the title compound (0.08 g, 12%).
  • 2
  • [ 475272-54-9 ]
  • [ 1211527-74-0 ]
  • [ 1435953-86-8 ]
YieldReaction ConditionsOperation in experiment
12% With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 - 110℃; Intermediate 8 7-[(2S)-2-Isopropylpiperazin-1-yl]thiazolo[5,4-d]pyrimidin-5-amine hydrochloride [0228] Intermediate 4 (2.2 mmol) and <strong>[475272-54-9]tert-butyl (3S)-3-isopropylpiperazine-1-carboxylate</strong> (0.5 g, 2.2 mmol) in DMF (10 mL) and DIPEA (0.34 g, 2.63 mmol) were heated at 110 C. for 6 h. The reaction mixture was allowed to cool, then stirred overnight at room temperature. The reaction mixture was concentrated in vacuo, then partitioned between EtOAc and water. The organic layers were dried over sodium sulfate and concentrated in vacuo, then the crude material was purified by column chromatography (silica gel: 100-200 mesh, isohexanes:EtOAc, gradient 50% to 100% EtOAc) to give an off-white foam. This was taken up in 4N HCl in 1,4-dioxane (5 mL) and methanol (1 mL), and stirred for 1 h. The reaction mixture was concentrated in vacuo and triturated with diethyl ether to give the title compound (0.08 g, 12%). LCMS (ES+) 279 (M+H)+, RT 0.91 minutes (method 3).
 

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