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Chemical Structure| 1211514-70-3 Chemical Structure| 1211514-70-3

Structure of 1211514-70-3

Chemical Structure| 1211514-70-3

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Product Details of [ 1211514-70-3 ]

CAS No. :1211514-70-3
Formula : C7H10N2S
M.W : 154.23
SMILES Code : NC(C1CC1)C1=NC=CS1
MDL No. :MFCD14628902

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Application In Synthesis of [ 1211514-70-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1211514-70-3 ]

[ 1211514-70-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 885521-46-0 ]
  • [ 1211514-70-3 ]
  • [ 1527515-57-6 ]
YieldReaction ConditionsOperation in experiment
52% With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0℃; for 1h; N-(Cyclopropyl(thiazol-2-yl)methyl)-3-iodo-1H-indazole-5-carboxamide The title compound was synthesized according to General Method A utilizing <strong>[885521-46-0]3-iodo-1H-indazole-5-carboxylic acid</strong> (255 mg, 0.88 mmol), cyclopropyl(thiazol-2-yl)methanamine (150 mg, 0.97 mmol), TBTU (310 mg, 0.97 mmol), DIPEA (0.31 mL, 1.8 mmol), and DMF (8 mL). The reaction was stirred at 0 C. for 1 h. The crude reaction was subsequently diluted with H2O. A filtration and washing (H2O) of the precipitate provided the desired product as a beige solid (195 mg, 52%). The product used without further purification. 1H NMR (400 MHz, CD3OD) delta ppm 8.16 (br. s., 1H), 7.99 (m., 1H), 7.77 (br. s., 1H), 7.46-7.67 (m, 2H), 1.45-1.68 (m, 1 H), 0.46-0.90 (m, 4H); MS ESI 425.0 [M+H]+, calcd for [C15H13IN4OS+H]+ 425.0.
 

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