Home Cart Sign in  
Chemical Structure| 1208308-11-5 Chemical Structure| 1208308-11-5

Structure of 1208308-11-5

Chemical Structure| 1208308-11-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1208308-11-5 ]

CAS No. :1208308-11-5
Formula : C5H6BNO3
M.W : 138.92
SMILES Code : OC1=CN=CC(B(O)O)=C1
MDL No. :MFCD13189132
InChI Key :LDIJJCLRXUCETJ-UHFFFAOYSA-N
Pubchem ID :56776577

Safety of [ 1208308-11-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 1208308-11-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1208308-11-5 ]

[ 1208308-11-5 ] Synthesis Path-Downstream   1~11

  • 1
  • [ 74115-13-2 ]
  • [ 73183-34-3 ]
  • [ 1171891-35-2 ]
  • [ 1208308-11-5 ]
YieldReaction ConditionsOperation in experiment
With 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; In 1,4-dioxane; at 80.0℃; for 2.0h;Inert atmosphere; General procedure: 5-Bromo-2-methoxypyridin-3-amine (1.73 g, 6.82 mmol) was dissolved in 50 mL dioxane. Bis(pinacolato)diboron (4.4 g, 17.33 mmol), potassium acetate (2.5 g, 25.47 mmol) were added and the mixture was submitted to three vacuum-argon cycles. Finally, bis(diphenylphosphino)ferrocene-palladium(ll)dichloride dichloromethane complex (0.9 g, 0.16 mmol) was added under argon conditions. The mixture was then heated at 80C for 2h. The crude was partitioned between ethyl acetate and water and then filtered through a plug of celite. The organic phase was dried over sodium sulphate, filtered and evaporated under reduced pressure. The residue was purified using SP1 Purification System (0% to 20%, hexane-ethyl acetate) to obtain 1.43g. This solid was triturated with hexane, filtered and dried in the oven to give 0.94 g (55% yield) of the desired product as a solid. 5-(4,4,5,5-Tetramethyl-1 ,3,2-dioxaborolan-2-yl)pyridin-3-ol 5-Bromopyridin-3-ol (3.70 g, 21.26 mmol) was treated with bis(pinacolato)diboron (10.80 g, 42.53 mmol), potassium acetate (6.26 g, 63.79 mmol) and bis(diphenylphosphino)ferrocene-palladium(ll)dichloride dichloromethane complex (1 .74 g, 2.13 mmol), 1 ,1 -bis(diphenylphosphino)ferrocene (1.18 g, 2.13 mmol) according to the method described in Preparation 42a to give 2.5 g (53 % yield) of the title compound as a mixture of boronate and boronic acid. Purity 100%. LRMS (m/z): 222 (M+1 )+.
  • 2
  • [ 4010-81-5 ]
  • [ 1208308-11-5 ]
  • [ 1062204-60-7 ]
  • 3
  • [ 1062204-82-3 ]
  • [ 1208308-11-5 ]
  • [ 1208308-09-1 ]
  • 4
  • [ 869120-25-2 ]
  • [ 1208308-11-5 ]
  • [ 1447449-93-5 ]
  • 5
  • [ 1208308-11-5 ]
  • [ 1610520-84-7 ]
  • [ 1610518-23-4 ]
YieldReaction ConditionsOperation in experiment
8% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,2-dimethoxyethane; water; at 120.0℃; for 0.5h;Microwave irradiation; A mixture of 7-bromo-5-methyl-2-((4-(methylsulphonyl)piperazin-1 -yl)methyl)thieno[3,2-c]pyridin- 4(5H)-one (for a preparation see Intermediate 69, 170 mg, 0.404 mmol), (5-hydroxypyridin-3- yl)boronic acid (399 mg, 2.87 mmol), potassium carbonate (279 mg, 2.022 mmol) and 5/s(triphenylphosphine)palladium(ll) chloride (17 mg, 0.024 mmol) in 1 ,2-dimethoxyethane (6 mL) and water (1 mL) was heated in the microwave at 120 C for 30 minutes. The cooled reaction mixture was diluted with ethyl acetate and an aqueous saturated solution of sodium bicarbonate was added. The phases were separated and the aqueous phase was extracted three times with ethyl acetate. The combined organic layers were washed with brine, dried over magnesium sulphate, filtered and concentrated in vacuo. The crude residue was purified via MDAP. The appropriate fractions were combined and concentrated in vacuo to give 7-(5-hydroxypyridin-3-yl)-5-methyl-2-((4- (methylsulphonyl)piperazin-1 -yl)methyl)thieno[3,2-c]pyridin-4(5H)-one (14 mg, 0.032 mmol, 8%) as a white solid. LCMS (2 min, Formic Acid): Rt = 0.42 min, MH+ = 435.
  • 6
  • [ 1208308-11-5 ]
  • C23H29ClN2O4 [ No CAS ]
  • 7
  • [ 1208308-11-5 ]
  • C17H19ClN2O2 [ No CAS ]
  • 8
  • [ 1208308-11-5 ]
  • [ 52807-27-9 ]
  • C12H10ClNO2 [ No CAS ]
  • 9
  • [ 1208308-11-5 ]
  • C8H8BrClO [ No CAS ]
  • C13H12ClNO2 [ No CAS ]
  • 10
  • [ 1208308-11-5 ]
  • C9H7BrClNO [ No CAS ]
  • C14H11ClN2O2 [ No CAS ]
  • 11
  • [ 1208308-11-5 ]
  • C9H7BrClNO [ No CAS ]
  • C14H11ClN2O2 [ No CAS ]
 

Historical Records

Technical Information

Categories