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Chemical Structure| 119671-47-5 Chemical Structure| 119671-47-5

Structure of 119671-47-5

Chemical Structure| 119671-47-5

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Product Details of [ 119671-47-5 ]

CAS No. :119671-47-5
Formula : C9H10ClNO3
M.W : 215.63
SMILES Code : O=C1C=C(Cl)OC(N2CCOCC2)=C1
MDL No. :MFCD28405027

Safety of [ 119671-47-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 119671-47-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 119671-47-5 ]

[ 119671-47-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 100124-07-0 ]
  • [ 119671-47-5 ]
  • [ 587871-28-1 ]
YieldReaction ConditionsOperation in experiment
41% With potassium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; at 90℃; for 24h;Sonication; Example 2 Synthesis of 2-Phenoxathiin-4-yl-6-morpholin-4-yl-pyran-4-one (5) 2-Chloro-6-morpholin-4-yl-pyran-4-one (3)(863 mg, 4 mmol), <strong>[100124-07-0]phenoxathiin-4-boronic acid</strong> (1.07 g, 4.4 mmol), and ground potassium carbonate (1.1 g, 8 mmol) were suspended in dioxane (10 ml) and degassed (sonication for 5 minutes then saturated with N2). Pd(PPh3)4 (231 mg, 0.2 mmol) was then added and the reaction mixture was then heated at 90 C. for 24 hours under a vigorous stirring and a N2 atmosphere. The solvent was removed in vacuo and the residue was then suspended in water (50 ml) and extracted with ethyl acetate (3*50 ml). The organics were combined, washed with saturated brine and dried over sodium sulphate. The solvent was removed in vacuo and the residue was purified by column chromatography (silica; ethyl acetate:ethanol; 9:1) to give the title compound as a white solid (620 mg, 41%). 1H-NMR (300 MHz, DMSO-d6): δ=3.38 (4H, t, J 5 Hz); 3.71 (4H, t, J 5 Hz); 5.49 (1H, d, J 2 Hz); 6.49 (1H, d, J 2 Hz); 7.06 (1H, dd, J 1 and 8 Hz); 7.26 (4H, m); 7.46 (1H, dd, J 1.5 and 8 Hz); 7.55 (1H, dd, J 1.5 and 8 Hz). m/z (LC-MS, ESP): 380 (M++1).
 

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