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Chemical Structure| 1192-07-0 Chemical Structure| 1192-07-0

Structure of 1192-07-0

Chemical Structure| 1192-07-0

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Product Details of [ 1192-07-0 ]

CAS No. :1192-07-0
Formula : C3H5NO2
M.W : 87.08
SMILES Code : O=C1NOCC1
MDL No. :MFCD11878032
InChI Key :QXDOFVVNXBGLKK-UHFFFAOYSA-N
Pubchem ID :192737

Safety of [ 1192-07-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 1192-07-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1192-07-0 ]

[ 1192-07-0 ] Synthesis Path-Downstream   1~35

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  • 26
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  • [ 821-10-3 ]
  • 3-(4-chloro-2-butynyl)oxy-Δ2-isoxazoline [ No CAS ]
  • [ 191277-31-3 ]
  • 29
  • [ 59617-25-3 ]
  • [ 7732-18-5 ]
  • furan-2,3,5(4H)-trione pyridine (1:1) [ No CAS ]
  • [ 1192-07-0 ]
  • 30
  • [ 108801-07-6 ]
  • methanol. KOH-solution [ No CAS ]
  • [ 1192-07-0 ]
  • 31
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  • 33
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  • [ 75-44-5 ]
  • [ 61982-49-8 ]
  • active charcoal [ No CAS ]
  • 7-(D-α-phenylglycylamido)-3-(1-methyl-1H-tetrazol-5-yl-thiomethyl)-3-cephem-4-carboxylic acid [ No CAS ]
  • 7-[D-2-(3-oxo-2-isoxazolidinecarboxamido)-2-phenylacetamido]-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; bis-(trimethylsilyl)acetamide; In tetrahydrofuran; dichloromethane; ethyl acetate; acetone; benzene; (11) A mixture of <strong>[1192-07-0]3-isoxazolidinone</strong> (700 mg) in tetrahydrofuran (30 ml) of phosgene (0.018 mole) was stirred at 0-5 C. for 3.5 hours and the solvent was removed. Tetrahydrofuran was added to the residue and the solvent was again removed. The residue was dissolved in benzene and benzene was removed by decantation, and the residue was further evaporated and dissolved in methylene chloride (5 ml). The resultant solution containing 3-oxo-2-isoxazolidinecarbonyl chloride was dropwise added to a solution of 7-(D-2-phenylglycinamido)-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid (2.0 g) and bis(trimethylsilyl)acetamide (3.2 g) in methylene chloride (50 ml) at 0-5 C. and the resultant mixture was stirred at 0-5 C. for 1.5 hour and at room temperature for an hour. After removal of the solvent, the residue was added to ethyl acetate (70 ml) and 5% hydrochloric acid (40 ml) and an insoluble substance was filtered off. The organic layer was washed with 5% hydrochloric acid and water and dried, and the solvent was distilled off under reduced pressure. The residue was pulverized with diethyl ether, the resultant crude powder (1.40 g) was treated with active charcoal in acetone and acetone was removed. The residue was pulverized with diethyl ether to give powder (0.94 g) of 7-[D-2-(3-oxo-2-isoxazolidinecarboxamido)-2-phenylacetamido]-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid, mp 138 to 144 C. (dec).
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  • [ 1116413-48-9 ]
  • [ 1116412-99-7 ]
  • 35
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  • [ 4390-96-9 ]
  • [ 1116412-92-0 ]
 

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