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[ CAS No. 118972-96-6 ] {[proInfo.proName]}

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Product Details of [ 118972-96-6 ]

CAS No. :118972-96-6 MDL No. :MFCD07366667
Formula : C5H9NO2 Boiling Point : -
Linear Structure Formula :- InChI Key :CSJAIVZAJZXEAW-UHFFFAOYSA-N
M.W : 115.13 Pubchem ID :11062345
Synonyms :

Safety of [ 118972-96-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 118972-96-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 118972-96-6 ]
  • Downstream synthetic route of [ 118972-96-6 ]

[ 118972-96-6 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 45347-82-8 ]
  • [ 75-36-5 ]
  • [ 118972-96-6 ]
YieldReaction ConditionsOperation in experiment
14% With triethylamine In tetrahydrofuran at -78 - 30℃; for 3.16667 h; Step 1-Synthesis of 1-(3-hydroxyazetidin-1-yl)ethan-1-one
To a solution of azetidin-3-ol (3.0 g, 27.40 mmol) and triethylamine (8.33 g, 82.48 mmol) in tetrahydrofuran (150 mL) was added acetyl chloride (2.15 g, 27.39 mmol) dropwise with stirring at -78° C. over 10 min.
The resulting solution was stirred for 3 h at 20-30° C.
The solid material was removed by filtration.
The filtrate was concentrated under vacuum and purified on a silica gel column (methanol/ethyl acetate (1/10)) to afford 500 mg (14percent) of 1-(3-hydroxyazetidin-1-yl)ethan-1-one as yellow oil. 1H NMR (400 MHz, DMSO) delta 3.60 (t, J=4.8 Hz, 2H), 2.83 (t, J=4.8 Hz, 2H), 2.21 (s, 3H).
Reference: [1] Patent: US2012/214762, 2012, A1, . Location in patent: Page/Page column 169
[2] Patent: US5130309, 1992, A,
  • 2
  • [ 143329-27-5 ]
  • [ 118972-96-6 ]
Reference: [1] Journal of Organic Chemistry, 1996, vol. 61, # 16, p. 5453 - 5455
[2] Tetrahedron Letters, 1998, vol. 39, # 31, p. 5481 - 5484
  • 3
  • [ 79-22-1 ]
  • [ 118972-96-6 ]
Reference: [1] Helvetica Chimica Acta, 1988, vol. 71, p. 1035 - 1041
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