Home Cart Sign in  
Chemical Structure| 1187487-23-5 Chemical Structure| 1187487-23-5

Structure of 1187487-23-5

Chemical Structure| 1187487-23-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1187487-23-5 ]

CAS No. :1187487-23-5
Formula : C12H13NO3
M.W : 219.24
SMILES Code : O=C(OCC1=CC=CC=C1)NCC(C=C)=O
MDL No. :MFCD24551551

Safety of [ 1187487-23-5 ]

Application In Synthesis of [ 1187487-23-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1187487-23-5 ]

[ 1187487-23-5 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 1187487-23-5 ]
  • [ 3963-62-0 ]
  • [ 125238-99-5 ]
  • [ 1185653-49-9 ]
YieldReaction ConditionsOperation in experiment
31% Example 17 - Synthesis of Compound 16 (S)-9-fluorenylmethyl 10-(2,2-diphenylethyl)- 2,2-dimethyl-18-phenyl-4,9,13,16-tetraoxo-3,17-dioxa-5,10,15-triazaoctadecan-8- ylcarbamate16(S)-9-fluorenylmethyl 10-(2,2-diphenylethyl)-2,2-dimethyl-18- phenyl-4,9,13,16-tetraoxo-3,17-dioxa-5,10,15-triazaoctadecan-8- ylcarbamateTo 2,2-diphenylethylamine (0.95 g, 7.4 mmol) in DCM (10 mL) was added the alphabeta- unsaturated ketone 15 (5.7 mmol) in DCM (75 mL). After stirring at room temperature for 15 mins, Fmoc-L-2,4-diaminobutyric acid(Boc)-OH (2.4 g, 8.55 mmol) and DIC (0.87 mL, 5.6 mmol) were added. The reaction was stirred at room temperature overnight. The DCM was removed by rotary evaporation and the residue was subjected to column chromatography on silica gel using petroleum spirit:EtOAc (1 :1 to 0:1 ) to give 16 (1.5 g, 31percent) Alternatively, to 2,2-diphenylethylamine (0.97 g, 7.4 mmol) in DCM (20 mL) was added the alpha,beta -unsaturated ketone 15 (5.95 mmol) in DCM (4OmL). After stirring at room temperature for 15 mins, Fmoc-L-2,4-diaminobutyric acid(Boc)-OH (2.4 g, 8.55 mmol), DIPEA (2.5 mL) and HATU (2.3 g, 6.0 mmol) were added. The reaction was stirred at room temperature overnight. The DCM was removed by rotary evaporation and the residue was taken up in EtOAc (100 mL). The organic layer was washed with saturated sodium bicarbonate solution (2x 100 mL), saturated ammonium chloride solution (2x 100 mL) and brine (2x 100 mL). The organic phase was dried and the solvent removed under reduced pressure. The residue was subjected to column chromatography on silica gel using petroleum spirit:EtOAc (3:1 to 1 :1 to 0:1 ) to give 16 (0.86 g, 17percent).
31% To 2,2-diphenylethylamine (0.95 g, 7.4 mmol) in DCM (10 ml.) was added the alphabeta- unsaturated ketone 15 (5.7 mmol) in DCM (75 ml_). After stirring at room temperature for 15 mins, Fmoc-L-2,4-diaminobutyric acid(Boc)-OH (2.4 g, 8.55 mmol) and DIC (0.87 ml_, 5.6 mmol) were added. The reaction was stirred at room temperature overnight. The DCM was removed by rotary evaporation and the residue was subjected to column chromatography on silica gel using petroleum spirit:EtOAc (1 :1 to 0:1 ) to give 16 (1.5 g, 31percent)
31% To 2,2-diphenylethylamine (0.95 g, 7.4 mmol) in DCM (10 mL) was added the alpha,beta-unsaturated ketone 15 (5.7 mmol) in DCM (75 mL).After stirring at room temperature for 15 mins, Fmoc-L-2,4-diaminobutyric acid(Boc)-OH (2.4 g, 8.55 mmol) and DIC (0.87 mL, 5.6 mmol) were added.The reaction was stirred at room temperature overnight.The DCM was removed by rotary evaporation and the residue was subjected to column chromatography on silica gel using petroleum spirit:EtOAc (1:1 to 0:1) to give 16 (1.5 g, 31percent)_
  • 2
  • [ 617-79-8 ]
  • [ 1187487-23-5 ]
  • [ 125238-99-5 ]
  • [ 1185654-07-2 ]
YieldReaction ConditionsOperation in experiment
46% Example 33 - Synthesis of Compound 28 (S)-9-fluorenylmethyl 10-(2-ethylbutyl)-2,2- dimethyl-18-phenyl-4,9,13,16-tetraoxo-3,17-dioxa-5,10,15-triazaoctadecan-8- ylcarbamate28(lSr)-9-fluorenylmethyl 10-(2-ethylbutyl)-2,2-dimethyl-18-phenyl- 4,9,13,16-tetraoxo-3,17-dioxa-5,10,15-triazaoctadecan-8- ylcarbamateTo 2-ethylbutylamine (0.15 g, 1.48 mmol) in DCM (10 mL) was added the alpha,beta- unsaturated ketone 15 (1.47 mmol) in DCM (30 mL). After stirring at room temperature for 15 mins, Fmoc-diaminobutyric acid(Boc)-OH (0.95 g, 2.16 mmol) and DIC (0.34 mL, 2.19 mmol) were added. The reaction was stirred at room temperature overnight. The DCM was removed by rotary evaporation and the residue was subjected to column chromatography on silica gel using petroleum spirit:EtOAc (1 :1 to 0:1 ), providing Compound 28 (0.5 g, 46percent).
46% To 2-ethylbutylamine (0.15 g, 1.48 mmol) in DCM (10 mL) was added the alpha,beta-unsaturated ketone 15 (1.47 mmol) in DCM (30 mL).After stirring at room temperature for 15 mins, Fmoc-diaminobutyric acid(Boc)-OH (0.95 g, 2.16 mmol) and DIC (0.34 mL, 2.19 mmol) were added.The reaction was stirred at room temperature overnight.The DCM was removed by rotary evaporation and the residue was subjected to column chromatography on silica gel using petroleum spirit:EtOAc (1:1 to 0:1), providing Compound 28 (0.5 g, 46percent).
  • 3
  • [ 1187487-23-5 ]
  • [ 20569-45-3 ]
  • [ 125238-99-5 ]
  • [ 1185653-65-9 ]
YieldReaction ConditionsOperation in experiment
21% Example 22 - Synthesis of Compound 19 (S)-9-fluorenylmethyl 10-(2-phenylbutyl)-2,2- dimethyl-18-phenyl-4,9,13,16-tetraoxo-3,17-dioxa-5,10,15-triazaoctadecan-8ylcarbamate19(5>;9-fluorenylmethyl 10-(2-phenylbutyl)-2,2-dimethyl-18-phenyl- 4,9,13,16-tetraoxo-3,17-dioxa-5,10,15-triazaoctadecan-8- ylcarbamateTo 2-phenylbutylamine hydrochloride (0.26 g, 1.4 mmol) in DCM (10 ml.) and DIPEA (0.25 ml_, 1.8 mmol) was added the alpha,beta-unsaturated ketone 15 (1.06 mmol) in DCM (20 ml_).After stirring at room temperature for 15 mins, Fmoc-diaminobutyric acid(Boc)-OH (0.7 g, 1.56 mmol) and DIC (0.25 ml_, 1.61 mmol) were added. The reaction was stirred at room temperature overnight. The DCM was removed by rotary evaporation and the residue was subjected to column chromatography on silica gel using petroleum spirit:EtOAc (1 :1 to 0:1 ), providing Compound 19 as a mixture of diastereomers (0.17 g, 21 percent).
21% To 2-phenylbutylamine hydrochloride (0.26 g, 1.4 mmol) in DCM (10 ml.) and DIPEA (0.25 ml_, 1.8 mmol) was added the alpha,beta-unsaturated ketone 15 (1.06 mmol) in DCM (20 ml_). After stirring at room temperature for 15 mins, Fmoc-diaminobutyric acid(Boc)-OH (0.7 g, 1.56 mmol) and DIC (0.25 ml_, 1.61 mmol) were added. The reaction was stirred at room temperature overnight. The DCM was removed by rotary evaporation and the residue was subjected to column chromatography on silica gel using petroleum spirit:EtOAc (1 :1 to 0:1 ), providing Compound 20 as a mixture of diastereomers (0.17 g, 21 percent).
21% To 2-phenylbutylamine hydrochloride (0.26 g, 1.4 mmol) in DCM (10 mL) and DIPEA (0.25 mL, 1.8 mmol) was added the alpha,beta-unsaturated ketone 15 (1.06 mmol) in DCM (20 mL).After stirring at room temperature for 15 mins, Fmoc-diaminobutyric acid(Boc)-OH (0.7 g, 1.56 mmol) and DIC (0.25 mL, 1.61 mmol) were added.The reaction was stirred at room temperature overnight.The DCM was removed by rotary evaporation and the residue was subjected to column chromatography on silica gel using petroleum spirit:EtOAc (1:1 to 0:1), providing Compound 19 as a mixture of diastereomers (0.17 g, 21percent).
  • 4
  • [ 1187487-23-5 ]
  • [ 125238-99-5 ]
  • [ 1185653-70-6 ]
 

Historical Records